DNAJC6 Antibody

中文名稱：

DNAJC6兔多克隆抗體
貨號：

CSB-PA007040LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA007040LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA007040LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA007040LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DNAJC6 Polyclonal antibody
Uniprot No.：

O75061
基因名：

DNAJC6
別名：

DNAJC6 antibody; KIAA0473 antibody; Putative tyrosine-protein phosphatase auxilin antibody; EC 3.1.3.48 antibody; DnaJ homolog subfamily C member 6 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Putative tyrosine-protein phosphatase auxilin protein (201-500AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，DNAJC6 Antibody (CSB-PA007040LA01HU)，的標記方式是Non-conjugated。對于DNAJC6 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA007040LB01HU	DNAJC6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA007040LC01HU	DNAJC6 Antibody, FITC conjugated
Biotin	CSB-PA007040LD01HU	DNAJC6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons.
基因功能參考文獻：
1. DNAJC6 mutations are not common causes of early onset Parkinson's disease in Chinese population PMID: 27687717
2. DNAJC6 mutations are associated with early-onset Parkinson's disease. PMID: 26528954
3. DNAJC6 is up-regulated in hepatocellular carcinoma tissues and up-regulation of DNAJC6 expression predicts poor outcome in patients with HCC PMID: 25446072
4. Missense mutations in DNAJC6 does not play a major role in PD in the Chinese population. PMID: 24126164
5. we did not detect any heterozygous or homozygous c.801-2A>G mutation in DNAJC6 in a cohort of Parkinson disease patients from southern Spain. PMID: 24220513
6. This review presented that DNAJC6 in recessive forms of juvenile parkinsonism. PMID: 24262182
7. Our findings further establish DNAJC6 as a juvenile parkinsonism gene, and expand the spectrums of the parkinsonism phenotype and DNAJC6 mutation PMID: 23211418
8. study reports a homozygous mutation in DNAJC6 in two patients with autosomal-recessive juvenile Parkinsonism; the mutation was associated with abnormal transcripts and marked reduced DNAJC6 mRNA level PMID: 22563501
9. The DNAJC6 gene encodes auxilin-1, a protein required for clathrin-dependent recycling of synaptic vesicles in neurons that is possibly at the origin of the mental retardation and epilepsy phenotype PMID: 22647716
10. there are two auxilins with overlapping functions; they not only facilitate the uncoating of clathrin-coated vesicles but also prevent the formation of nonproductive clathrin cages in the cytosol PMID: 18489706
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相關疾病：

Parkinson disease 19A, juvenile-onset (PARK19A); Parkinson disease 19B, early-onset (PARK19B)
組織特異性：

Expressed in various brain regions, including cerebellum, corpus callosum, cortex, striatum, brainstem, pons, putamen, spinal cord and substantia nigra. Very low expression in non-neural tissues such as leukocytes, liver, adipose tissue, skeletal muscle a
數據庫鏈接：

HGNC: 15469

OMIM: 608375

KEGG: hsa:9829

STRING: 9606.ENSP00000378735

UniGene: Hs.647643

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