DNAJC2 Antibody

說明書

中文名稱：

DNAJC2兔多克隆抗體
貨號：

CSB-PA858715ESR2HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA858715ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA858715ESR2HU at dilution of 1:100
其他：

產品詳情
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相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DNAJC2 Polyclonal antibody
Uniprot No.：

Q99543
基因名：

DNAJC2
別名：

AU020218 antibody; DnaJ (Hsp40) homolog subfamily C member 2 antibody; DnaJ homolog subfamily C member 2 antibody; Dnajc2 antibody; DNJC2_HUMAN antibody; M phase phosphoprotein 11 antibody; M-phase phosphoprotein 11 antibody; MGC105894 antibody; MIDA1 antibody; MPHOSPH11 antibody; MPP11 antibody; OTTMUSP00000031226 antibody; ZRF1 antibody; Zrf2 antibody; ZUO1 antibody; Zuotin related factor 1 antibody; Zuotin related factor 2 antibody; Zuotin-related factor 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human DnaJ homolog subfamily C member 2 protein (1-140AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
基因功能參考文獻：
1. These findings suggest that ZRF1 plays a crucial role in tumor malignant potential through its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in gastric cancer PMID: 29228320
2. Unexplored functions of ZRF1-mediated remodeling in replication and double strand break repair are discussed. PMID: 27599465
3. ZRF1 mediates remodeling of this E3 ligase complex directly at the DNA lesion site. PMID: 27091446
4. The antibody response to ZRF1 was higher in sera of patients with invasive ductal carcinoma than in sera of patients with other histological types of breast tumors. PMID: 27847402
5. Zrf1 is transcriptional regulator of neural fate downstream of Id1 in embryonic stem cells.During embryonic stem cell differentiation, Id1 levels decrease allowing Zrf1 to activate neural genes. PMID: 25361733
6. our data reveal that ZRF1 is a key transcriptional regulator in leukemia progression PMID: 24292673
7. Zrf1 plays an essential role in neural progenitor cell generation and maintenance PMID: 24449271
8. ZRF1 regulates the INK4-ARF locus during cellular proliferation and senescence, and alterations in ZRF1 may contribute to tumorigenesis. PMID: 22733129
9. the majority of AML patients elicited a humoral immune response against the tumor antigen MPP11 PMID: 22433847
10. describe a novel epitope derived from the MPP11 antigen that has been recognized by human CD8+ CTL PMID: 20231810
11. At the onset of differentiation, ZRF1 specifically displaces polycomb-repressive complex 1 (PRC1) from chromatin and facilitates transcriptional activation PMID: 21179169
12. concluded that Mpp11, an ortholog of yeast Zuo, is a ribosome-associated J protein; proposed that in metazoans, ribosome-associated Zuo and Mpp11 orthologs recruit cytosolic Hsc70 to short ribosome-bound nascent chains as they exit the ribosome PMID: 15802566
13. MPP11 is localized to the cytosol and with Hsp70L1, forms the mammalian ribosome-associated complex. PMID: 16002468
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亞細胞定位：

Nucleus. Cytoplasm, cytosol.
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 13192

OMIM: 605502

KEGG: hsa:27000

STRING: 9606.ENSP00000368565

UniGene: Hs.558476

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