DNAJB9 Antibody
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中文名稱：DNAJB9兔多克隆抗體
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貨號：CSB-PA866205ESR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA866205ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA866205ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) DNAJB9 Polyclonal antibody
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Uniprot No.：
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基因名：DNAJB9
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別名：DKFZP564F1862 antibody; DnaJ (Hsp40) homolog subfamily B member 9 antibody; DnaJ homolog subfamily B member 9 antibody; DNAJB9 antibody; DNJB9_HUMAN antibody; eEndoplasmic reticulum DNA J domain containing protein 4 antibody; Endoplasmic reticulum DnaJ homolog 4 antibody; ER resident protein ERdj4 antibody; ERdj4 antibody; MDG 1 antibody; Mdg-1 antibody; MDG1 antibody; Microvascular endothelial differentiation gene 1 antibody; Microvascular endothelial differentiation gene 1 protein antibody; MST049 antibody; MSTP049 antibody; OTTHUMP00000206840 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human DnaJ homolog subfamily B member 9 protein (24-223AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production.
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基因功能參考文獻：
- Study reports that the endoplasmic reticulum luminal co-chaperone ERdj4/DNAJB9 is a selective IRE1 repressor that promotes a complex between the luminal Hsp70 BiP and the luminal stress-sensing domain of IRE1alpha. PMID: 29198525
- these results demonstrate that DNAJB9 is a downstream target of p53 that belongs to the group of negative feedback regulators of p53. PMID: 25146923
- ERdj4 and ERdj5 promote turnover of misfolded SP-C and this activity is dependent on their ability to stimulate BiP ATPase activity. PMID: 18400946
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亞細胞定位：Endoplasmic reticulum lumen.
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組織特異性：Widely expressed. Expressed at highest level in the liver, placenta and kidney.
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數據庫鏈接：
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