DNAJA1 Antibody

說明書

中文名稱：

DNAJA1兔多克隆抗體
貨號：

CSB-PA004998
規格：

￥1090
圖片：
Western Blot analysis of mouse liver mouse kidney mouse brain cells using HSP40-4 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P31689
基因名：

DNAJA1
別名：

DJ 2 antibody; DJ2 antibody; DjA1 antibody; DnaJ (Hsp40) homolog; subfamily A; member 1 antibody; DnaJ homolog subfamily A member 1 antibody; DnaJ protein homolog 2 antibody; DNAJ2 antibody; Dnaja1 antibody; DNJA1_HUMAN antibody; hDJ 2 antibody; HDJ-2 antibody; HDJ2 antibody; Heat shock 40 kDa protein 4 antibody; heat shock protein DNAJ like 2 antibody; Heat shock protein J2 antibody; HSDJ antibody; HSJ-2 antibody; HSJ2 antibody; HSPF4 antibody; Human DnaJ protein 2 antibody; NEDD7 antibody; Neural precursor cell expressed developmentally down regulated 7 antibody; OTTHUMP00000021193 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human HSP40-4.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Co-chaperone for HSPA8/Hsc70. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV.
基因功能參考文獻：
1. that DNAJA1 controls the fate of misfolded stabilization of mutant p53 PMID: 27775703
2. Therefore, we propose that DnaJA1 is co-opted by the influenza A virus to enter the nucleus and to enhance its RNA polymerase activity in an Hsp70 cochaperone-independent manner. PMID: 25253355
3. structure and function of human DNAJA1 and its relationship to pancreatic cancer PMID: 24512202
4. we combined the Hsp70-NEF pairs with cochaperones of the J protein family (DnaJA1, DnaJA2, DnaJB1, and DnaJB4) to generate 16 permutations. PMID: 24318877
5. Moreover, the levels of DnaJA1 and Hsp70 seem to play against each other with regard to tau: as DnaJA1 levels increase, tau levels are reduced, but this can be prevented if Hsp70 levels are simultaneously induced. PMID: 22343013
6. Hdj2 directly associates with Japanese encephalitis virus nonstructural protein NS5 and facilitates viral replication. PMID: 21999493
7. Hsc70 and a dimer of DjA1 independently bind to an unfolded protein PMID: 20363747
8. Hsp40 type 1 chaperones DJA1 (DNAJA1/Hdj2) and DJA2 (DNAJA2) as key modulators of hERG degradation PMID: 19940115
9. Mammalian, yeast, bacterial, and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy PMID: 11796717
10. HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor PMID: 11809754
11. sequence analysis of two isoforms PMID: 12974469
12. Multiple tissue polymerase chain reaction (PCR) results showed that nDnaJA1 expressed highly in testis and lung but low in thymus, prostate, colon and liver PMID: 15595953
13. Results indicate that DjA1 and DjB4 of subfamilies A and B of human Hsp40 have different quaternary structures and chaperone functions. PMID: 15661747
14. DJA1 was inhibitory of refolding with DJA2 and Hsc70. PMID: 18684711
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亞細胞定位：

Membrane; Lipid-anchor. Cytoplasm. Microsome. Nucleus. Cytoplasm, perinuclear region. Mitochondrion.
組織特異性：

Ubiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver.
數據庫鏈接：

HGNC: 5229

OMIM: 602837

KEGG: hsa:3301

STRING: 9606.ENSP00000369127

UniGene: Hs.445203

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