DNAH1 Antibody

文獻(xiàn)引用 (2) 說(shuō)明書(shū)

中文名稱：

DNAH1兔多克隆抗體
貨號(hào)：

CSB-PA878961LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA878961LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA878961LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA878961LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
引用文獻(xiàn)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) DNAH1 Polyclonal antibody
Uniprot No.：

Q9P2D7
基因名：

DNAH1
別名：

DNAH1 antibody; DHC7 antibody; DNAHC1 antibody; KIAA1410 antibody; Dynein heavy chain 1 antibody; axonemal antibody; Axonemal beta dynein heavy chain 1 antibody; Ciliary dynein heavy chain 1 antibody; Heat shock regulated protein 1 antibody; HSRF-1 antibody; hDHC7 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Dynein heavy chain 1, axonemal protein (2225-2407AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，DNAH1 Antibody (CSB-PA878961LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于DNAH1 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA878961LB01HU	DNAH1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA878961LC01HU	DNAH1 Antibody, FITC conjugated
Biotin	CSB-PA878961LD01HU	DNAH1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻(xiàn)

DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice X Wang, G Shen, Y Yang, C Jiang, T Ruan, X Yang,eLife,2024
Biallelic pathogenic variants in DNAH3 cause male infertility in humans and mice X Wang,Human reproduction open,2024

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme.
基因功能參考文獻(xiàn)：
1. DNAH1 variations were identified in 6 of 287 patients, including 8 heterozygous variations in exons and a splicing site. 4 variations (g.52400764G>C, g.52409336C>T, g.52430999_52431000del, g.52412624C>A) had already been registered in the 1000 Genomes and Exome Aggregation Consortium databases. The other novel variations (g.52418050del, g.52404762T>G, g.52430536del, g.52412620del) were all predicted to be pathogenic. PMID: 30544445
2. Pedigree analysis supported the notion that the combination of DNAH1 gene mutations 52430998CCT>C and 52409336C>T and 52428484G>T alone were associated with MMAF. CONCLUSION(S): These DNAH1 gene mutations may be associated with DFS and infertility in the Han population. PMID: 28577616
3. This mutation was distinct from previously reported DNAH1 mutations associated with MMAF and only affected the East Asian group. Furthermore, the variant DNAH1 protein could not be detected in spermatozoa by Western blot or immunofluorescence staining although DNAH1 mRNA was expressed in the spermatozoa. PMID: 27573432
4. variation in DNAH1 may play a role in primary ciliary dyskinesia PMID: 25927852
5. Although DNAH1 is expressed in other ciliated cells, infertility was the only symptom of primary ciliary dyskinesia observed in affected subjects, suggesting that DNAH1 function in cilium is not as critical as in sperm flagellum. PMID: 24360805
6. Male carriers of the mutations always exhibit asthenozoospermia, whereas female carriers manifest no alterations in either fertility or pulmonary clearance. PMID: 18492703
7. Dynein motor function is important for regulating Gag and viral RNA egress on endosomal membranes in the cytoplasm to directly impact on viral production. PMID: 19286658
8. clathrin serving as a regulator of SNX4-dependent transport; upon clathrin release, dynein may bind SNX4 and mediate retrograde movement PMID: 19529763
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相關(guān)疾病：

Spermatogenic failure 18 (SPGF18); Ciliary dyskinesia, primary, 37 (CILD37)
亞細(xì)胞定位：

Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, flagellum.
蛋白家族：

Dynein heavy chain family
組織特異性：

Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 2940

OMIM: 603332

KEGG: hsa:25981

STRING: 9606.ENSP00000401514

UniGene: Hs.655469

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