DLST Antibody

中文名稱：

DLST兔多克隆抗體
貨號：

CSB-PA861526LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Rat liver tissue, Rat kidney tissue
All lanes: DLST antibody at 5.9μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 49, 40 kDa
Observed band size: 49 kDa

IHC image of CSB-PA861526LA01HU diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA861526LA01HU diluted at 1:300 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of HepG2 cells with CSB-PA861526LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DLST Polyclonal antibody
Uniprot No.：

P36957
基因名：

DLST
別名：

2-oxoglutarate dehydrogenase complex component E2 antibody; Dihydrolipoamide S succinyltransferase (E2 component of 2 oxo glutarate complex) antibody; Dihydrolipoamide S succinyltransferase antibody; Dihydrolipoamide succinyltransferase component of 2 oxoglutarate dehydrogenase complex antibody; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex antibody; Dihydrolipoyllysine residue succinyltransferase component of 2 oxoglutarate dehydrogenase complex antibody; Dihydrolipoyllysine residue succinyltransferase component of 2 oxoglutarate dehydrogenase complex mitochondrial antibody; Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex antibody; Dlst antibody; DLTS antibody; E2 antibody; E2K antibody; mitochondrial antibody; ODO2_HUMAN antibody; OGDC-E2 antibody
宿主：

Rabbit
反應種屬：

Human, Rat
免疫原：

Recombinant Human Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial protein (76-225AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，DLST Antibody (CSB-PA861526LA01HU)，的標記方式是Non-conjugated。對于DLST Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA861526LB01HU	DLST Antibody, HRP conjugated	ELISA
FITC	CSB-PA861526LC01HU	DLST Antibody, FITC conjugated
Biotin	CSB-PA861526LD01HU	DLST Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.
基因功能參考文獻：
1. RNAi knockdown of DLST led to decreased cell viability and induction of apoptosis in human T-ALL cell lines PMID: 26876595
2. 2-oxoglutarate dehydrogenase complex (OGDHC), the key regulatory enzyme of Krebs cycle. [review] PMID: 22235656
3. Data show that the dihydrolipoamide succinyltransferase gene is bifunctional, and truncated mRNA transcribed from it contributes to the biogenesis of the mitochondrial respiratory complexes. PMID: 12805207
4. Association between late-onset Alzheimer disease shows strong linkage disequilibrium across the DLST locus. PMID: 15038610
亞細胞定位：

Mitochondrion matrix. Nucleus.
蛋白家族：

2-oxoacid dehydrogenase family
數據庫鏈接：

HGNC: 2911

OMIM: 126063

KEGG: hsa:1743

STRING: 9606.ENSP00000335304

UniGene: Hs.525459

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