DIS3 Antibody

中文名稱：

DIS3兔多克隆抗體
貨號：

CSB-PA897532LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA897532LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DIS3 Polyclonal antibody
Uniprot No.：

Q9Y2L1
基因名：

DIS3
別名：

2810028N01Rik antibody; bA555G22 antibody; Dis3 antibody; DIS3 homolog; exosome endoribonuclease and 3'-5' exoribonuclease antibody; DIS3 mitotic control homolog (S. cerevisiae) antibody; DIS3 mitotic control homolog antibody; DIS3 mitotic control; S. cerevisiae; homolog of antibody; dis3p antibody; EXOSC11 antibody; Exosome complex exonuclease RRP44 antibody; exosome component 11 antibody; KIAA1008 antibody; Mitotic control protein dis3 homolog antibody; Protein DIS3 homolog antibody; Ribosomal RNA processing protein 44 antibody; Ribosomal RNA processing protein 44; S. cerevisiae; homolog of antibody; Ribosomal RNA-processing protein 44 antibody; RP11-342J4.3 antibody; RRP44 antibody; RRP44_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Exosome complex exonuclease RRP44 protein (30-187AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，DIS3 Antibody (CSB-PA897532LA01HU)，的標記方式是Non-conjugated。對于DIS3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA897532LB01HU	DIS3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA897532LC01HU	DIS3 Antibody, FITC conjugated
Biotin	CSB-PA897532LD01HU	DIS3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.
基因功能參考文獻：
1. The 3.8 A resolution cryo-EM structure of the core complex bound to a single-stranded RNA reveals that the RNA channel path is formed by two distinct features of the hDIS3 exoribonuclease: an open conformation and a domain organization more similar to bacterial RNase II than to yeast Rrp44. PMID: 30047866
2. Results from a study on gene variability markers in early-stage human embryos shows that DIS3 is a putative variability marker for the 3-day, 8-cell embryo stage, identified by mixture models as well as standard ANOVA. PMID: 26288249
3. Authors have identified a putative functional indel variant at chr13q22.1 that associates with decreased DIS3 expression in carriers of pancreatic cancer risk-increasing alleles, and could therefore affect nuclear RNA processing and/or decay. PMID: 28172817
4. Data indicate the pathological relevance of exosome component 11 protein (DIS3) mutations in plasma cell dyscrasias and suggest that DIS3 may represent a potential tumor suppressor gene in such disorders. PMID: 26305418
5. structure and function of DIS3 PMID: 26193331
6. The study establishes that the ribonuclease DIS3, targeting LIN28B, sustains the maturation of let-7 miRNAs and suggests the increased translation of critical oncogenes as one of the biological outcomes of DIS3 inactivation. PMID: 25925570
7. seven novel somatic DIS3 single nucleotide variants (SNVs) and defined three hot spot mutations within the RNB domain. PMID: 25521164
8. Overexpression of DIS3 and LRCH1 associated with adenoma to carcinoma progression is linked to the colorectal cancer specific gain of 13q. PMID: 24478024
9. Multiple myeloma-associated hDIS3 mutations interfere with hDIS3 exonucleolytic activity. PMID: 24150935
10. Data show that hDIS3 and hDIS3L are active exonucleases, but only hDIS3 has retained endonucleolytic activity, and suggest that three different ribonucleases can serve as catalytic subunits for the exosome in human cells. PMID: 20531386
11. S. cerevisiae Dis3p is identical to Rrp44p, which comprises the exosome involved in ribosomal RNA processing, S. cerevisiae Dis3p was found to be localized in the nucleolus. PMID: 9562621
12. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. There appears to be no interaction between human dis3 and other exosome subunits, however. PMID: 12419256
13. Dis3p is identical to Rrp44p, which comprises the exosome involved in ribosomal RNA processing. Similar to S. cerevisiae Dis3p, human Dis3p enhanced RCC1-stimulated nucleotide release from Ran, in a dose-dependent manner, and bound to GTP- or GDP-Ran. PMID: 9562621
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亞細胞定位：

Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus.
蛋白家族：

RNR ribonuclease family
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 20604

OMIM: 607533

KEGG: hsa:22894

STRING: 9606.ENSP00000366997

UniGene: Hs.744104

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