DIRAS1 Antibody

說明書

中文名稱：

DIRAS1兔多克隆抗體
貨號：

CSB-PA550322
規格：

￥2024
圖片：
Western blot analysis of extracts from HeLa cells and HepG2 cells, using DIRA1 antibody.
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DIRAS1 Polyclonal antibody
Uniprot No.：

O95057
基因名：

DIRAS1
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from C-terminal of Human DIRA1.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Displays low GTPase activity and exists predominantly in the GTP-bound form.
基因功能參考文獻：
1. This neuronal DIRAS1 gene with a proposed role in cholinergic transmission provides not only a candidate for human myoclonic epilepsy but also insights into the disease etiology, while establishing a spontaneous model for future intervention studies and functional characterization. PMID: 28223533
2. Results show that DIRAS1 is frequently methylated in human colorectal cancer and the expression of DIRAS1 is silenced by promoter region methylation. PMID: 28491151
3. DiRas1 expression inhibits malignant features of cancers in part by nonproductively binding to SmgGDS and inhibiting the binding of other small GTPases to SmgGDS PMID: 26814130
4. DIRAS1 downregulation is associated with esophageal squamous cell carcinoma metastasis. PMID: 23436800
5. a novel Ras-related protein and potential neural tumor suppressor (RIG) PMID: 12107278
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亞細胞定位：

Cell membrane; Lipid-anchor; Cytoplasmic side.
蛋白家族：

Small GTPase superfamily, Di-Ras family
組織特異性：

Highly expressed in heart and brain.
數據庫鏈接：

HGNC: 19127

OMIM: 607862

KEGG: hsa:148252

STRING: 9606.ENSP00000325836

UniGene: Hs.172753

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