DHX36 Antibody

中文名稱：

DHX36兔多克隆抗體
貨號：

CSB-PA862002LA01HU
規格：

￥440
圖片：
Immunofluorescent analysis of U251 cells using CSB-PA862002LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DHX36 Polyclonal antibody
Uniprot No.：

Q9H2U1
基因名：

DHX36
別名：

DDX36 antibody; DEAH box protein 36 antibody; Dhx36 antibody; DHX36_HUMAN antibody; EC 3.6.1.- antibody; KIAA1488 antibody; MLE like protein 1 antibody; MLE-like protein 1 antibody; MLEL1 antibody; Probable ATP dependent RNA helicase DHX36 antibody; Probable ATP-dependent RNA helicase DHX36 antibody; RHAU antibody; RNA helicase associated with AU rich element ARE antibody; RNA helicase associated with AU-rich element ARE antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human ATP-dependent RNA helicase DHX36 protein (68-181AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，DHX36 Antibody (CSB-PA862002LA01HU)，的標記方式是Non-conjugated。對于DHX36 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA862002LB01HU	DHX36 Antibody, HRP conjugated	ELISA
FITC	CSB-PA862002LC01HU	DHX36 Antibody, FITC conjugated
Biotin	CSB-PA862002LD01HU	DHX36 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures. Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses. G4 structures correspond to helical structures containing guanine tetrads. Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA). Plays a role in genomic integrity. Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription. Plays a role in transcriptional regulation. Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression. Plays a role in post-transcriptional regulation. Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage. Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment. Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size. Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability. Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression. Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively. Binds also to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation. Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1. Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification.
基因功能參考文獻：
1. Data show that helicases RHAU, BLM, and WRN exhibit distinct G-quadruplex (GQ) conformation specificity, but use a common mechanism of repetitive unfolding that leads to disrupting GQ structure multiple times in succession. PMID: 27407146
2. RHAU mediates the unfolding of DNA and RNA quadruplexes. PMID: 28065761
3. The study provides the first evidence that the unfolding kinetics of a G-quadruplex can be modulated by different nucleotide-bound states of the RHAU helicase. PMID: 28069994
4. RHAU binds to an adenosine-rich region near the 3'-end of the long non-coding RNA BC200. PMID: 26740632
5. present a model showing that a replication fork disrupting a T-loop could create a 5' quadruplex with an opened 3'tail structure that is recognized by G4R1 PMID: 26172836
6. we identify a novel function of DHX36 to facilitate viral RNA recognition PMID: 24651521
7. Used an integrated approach that includes small angle x-ray scattering, nuclear magnetic resonance spectroscopy, circular dichroism, and dynamic light scattering methods to demonstrate the recognition of G-quadruplexes by the N-terminal domain of RHAU. PMID: 24151078
8. Data supports a helicase function of RHAU on an intramolecular RNA quadruplex and show that the enzyme is capable of completely converting quadruplex RNA to a stable duplex. PMID: 22238380
9. Data show that hnRNPA1/A2, HuR and DAZAP1 splicing factors and DHX36 RNA helicase bind to the ISE, with hnRNPA1 acting negatively and DAZAP1 positively on splicing selection PMID: 21858080
10. The helicase domain of DHX36 does not mediate telomerase RNA (hTR) binding; instead, hTR interacts with the N-terminal accessory domain of DHX36 known to bind specifically to the parallel-strand G-quadruplex substrates resolved by the helicase domain. PMID: 21149580
11. The amino-terminal region of RHAU is essential for RHAU to bind G4 structures and within this region the evolutionary conserved RSM (RHAU-specific motif) domain is a major affinity and specificity determinant PMID: 20472641
12. DHX9/DHX36 represent the MyD88-dependent DNA sensors in the cytosol of plasmacytoid dendritic cells and suggest a much broader role for DHX helicases in viral sensing PMID: 20696886
13. DHX36 protein is responsible for the majority of tetramolecular G4-DNA resolvase activity PMID: 16150737
14. RHAU has a dual function, being involved in both the synthesis and degradation of mRNA in different subcellular compartments. PMID: 18279852
15. the RNA quadruplex resolving enzymatic activity associated with G4R1/RHAU and its exceptional binding affinity, suggesting a potential novel role for G4R1/RHAU in targeting in vivo RNA quadruplex structures PMID: 18842585
16. RHAU is the fourth RNA helicase detected in SGs, after rck/p54, DDX3, and eIF4A, and its association with SGs is dynamic and mediated by an RHAU-specific RNA-binding domain PMID: 18854321
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亞細胞定位：

Nucleus. Cytoplasm. Cytoplasm, cytosol. Cytoplasm, Stress granule. Nucleus speckle. Chromosome, telomere. Mitochondrion. Perikaryon. Cell projection, dendrite. Cell projection, axon.; [Isoform 1]: Nucleus. Cytoplasm.; [Isoform 2]: Nucleus. Cytoplasm.
蛋白家族：

DEAD box helicase family, DEAH subfamily
組織特異性：

Highly expressed in testis.
數據庫鏈接：

HGNC: 14410

OMIM: 612767

KEGG: hsa:170506

STRING: 9606.ENSP00000417078

UniGene: Hs.446270

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