DEDD Antibody
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中文名稱：DEDD兔多克隆抗體
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貨號：CSB-PA006648ESR2HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA006648ESR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006648ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) DEDD Polyclonal antibody
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Uniprot No.：
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基因名：DEDD
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別名：CASP8IP1 antibody; Death effector domain containing antibody; Death effector domain containing protein antibody; Death effector domain containing testicular molecule antibody; Death effector domain-containing protein antibody; Death effector domain-containing testicular molecule antibody; DEDD 1 antibody; dedD antibody; DEDD_HUMAN antibody; DEDD1 antibody; DEDPro 1 antibody; DEDPro1 antibody; DEFT antibody; FLDED 1 antibody; FLDED-1 antibody; FLDED1 antibody; KE 05 antibody; KE05 antibody; OTTHUMP00000031822 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Death effector domain-containing protein (1-318AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro.
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基因功能參考文獻：
- LINC00472 contributed to the increase in lung adenocarcinoma cell apoptosis and the inhibition of proliferation via regulating miR-24-3p/ DEDD. PMID: 30175664
- DEDD protein role in cell proliferation and migration of bladder cancer PMID: 28000900
- Via direct interaction with the class III PI-3-kinase (PI3KC3)/Beclin1, DEDD activated autophagy and induced the degradation of Snail and Twist, two master regulators of EMT PMID: 22719072
- FAS-associated death domain (FADD)-DED-induced reactive oxygen species (ROS) generation is triggered by membrane localization of FADD-DED, which shifts the cells into a state that stimulates and fuels ROS and ultimately results in cell death. PMID: 20070122
- DEDD forms nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC PMID: 11965497
- DEDD and DEDD2 may be important mediators for death receptors and that they may target caspases to the nucleus. PMID: 12527898
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亞細胞定位：Cytoplasm. Nucleus, nucleolus.
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組織特異性：Widely expressed with highest levels in testis.
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數據庫鏈接：
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