DDX53 Antibody

說明書

中文名稱：

DDX53兔多克隆抗體
貨號：

CSB-PA801951
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA801951(DDX53 Antibody) at dilution 1/75, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA801951(DDX53 Antibody) at dilution 1/75, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HepG2 cells, Primary antibody: CSB-PA801951(DDX53 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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靶點詳情

產品詳情

Uniprot No.：

Q86TM3
基因名：

DDX53
別名：

CAGE antibody; Cancer associated gene protein antibody; Cancer-associated gene protein antibody; Cancer/testis antigen 26 antibody; CT26 antibody; DDX53 antibody; DDX53_HUMAN antibody; DEAD (Asp Glu Ala Asp) box polypeptide 53 antibody; DEAD box protein 53 antibody; DEAD box protein CAGE antibody; Probable ATP dependent RNA helicase DDX53 antibody; Probable ATP-dependent RNA helicase DDX53 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Fusion protein of Human DDX53
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:10000
WB	1:200-1:1000
IHC	1:100-1:300

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

基因功能參考文獻：
1. A novel role of DDX53 in regulating cancer stem cell-like properties by binding to SOX-2.DDX53 directly regulates the SOX-2 expression in drug-resistant melanoma cells. PMID: 28535666
2. DDX53 promotes stem cell-like properties, autophagy, and confers resistance to anti-cancer drugs in breast cancer cells. PMID: 28152297
3. Results provide evidence that miR-30a forms a positive feedback loop with CAGE to regulate the expression of p53 confering resistance to anti-cancer drugs. PMID: 26912082
4. miR-217-CAGE feedback loop serves as a target for overcoming resistance to various anti-cancer drugs, including EGFR and HER2 inhibitors. PMID: 26863629
5. Results show the direct regulation of CAGE expression by HDAC3 and that HDAC3-CAGE axis regulates the activation of EGFR. HDAC3 targets CAGE to regulate the tumorigenic potential and angiogenic potential of cancer cells. PMID: 26883907
6. CAGE induced the interaction between histone deacetylase 2 (HDAC2) and Snail, which exerted a negative effect on p53 expression in neoplastic cells; CAGE confers drug resistance by regulating expression of p53 through HDAC2. PMID: 20534591
7. CAGE is expressed in a variety of cancers but not in normal tissues except testis, and might play a role in cellular proliferation. PMID: 11922625
8. results suggest that the methylation status of the CpG sites of CAGE determines its expression, and that hypomethylation of CAGE precedes the development of gastric cancer and hepatocellular carcinoma PMID: 12849980
9. CAGE promotes motility of cancer cells through activation of focal adhesion kinase (FAK). PMID: 17028776
10. Hypomethylated CAGE promoter CpG islands are frequently involved in uterine cervical carcinogenesis. PMID: 17341616
11. The CAGE gene is widely expressed in various cancer tissues and cancer cell lines. PMID: 18388483
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亞細胞定位：

Nucleus.
蛋白家族：

DEAD box helicase family
組織特異性：

Expressed in testis. Wide expression in various cancer tissues and cancer cell lines.
數據庫鏈接：

HGNC: 20083

KEGG: hsa:168400

STRING: 9606.ENSP00000368667

UniGene: Hs.434416

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