DDX3Y Antibody

說明書

中文名稱：

DDX3Y兔多克隆抗體
貨號：

CSB-PA070114
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O15523
基因名：

DDX3Y
別名：

ATP dependent RNA helicase DDX3Y antibody; ATP-dependent RNA helicase DDX3Y antibody; DBY antibody; DDX3Y antibody; DDX3Y_HUMAN antibody; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 Y linked antibody; DEAD box protein 3 Y chromosomal antibody; DEAD box protein 3 antibody; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide Y chromosome antibody; Y-chromosomal antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the N-terminal region of Human DDX3Y.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:20000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway.
基因功能參考文獻：
1. DDX3Y gene rescue of a Y chromosome AZFa deletion restores germ cell formation and transcriptional programs. PMID: 26456624
2. results suggest that MSY genes may play an important role in neural differentiation and demonstrate that DDX3Y could play a multifunctional role in neural cell development PMID: 26144214
3. fetal germ cell DDX3Y protein expression suggests a role in early spermatogonial proliferation PMID: 22466863
4. We show here the development of a coordinated B and T-cell response to DBY in a recipient of sex mismatched allogeneic hematopoietic stem-cell transplantation. PMID: 21709606
5. Gene structure of the human DDX3 and chromosome mapping of its related sequences.Its organization was the same as that of the human DBY gene, a closely related sequence present on the Y chromosome. PMID: 11710523
6. graft-versus-host (GVH) disease after HLA-identical stem cell transplantation is the result of recognition of minor histocompatibility antigens (mHags) by immunocompetent T lymphocytes from recipient origin. PMID: 11929796
7. coordinated B and T cell immune response to H-Y minor histocompatibility antigen, DBY, after allogeneic transplant PMID: 15096539
8. Human Y- and X-encoded DEAD box RNA helicase proteins DDX3Y and DDX3X are interchangeable and have an essential function. Ddx3x mRNA was expressed in almost every cell in mouse testis, suggesting that Ddx3x is involved in spermatogenesis PMID: 15383328
9. The finding that the testicular transcript of DDX3Y is significantly decreased in patients with severe spermatogenenic failure, especially in those presenting maturation arrest, suggests an important role of DDX3Y during spermatogenesis. PMID: 17881721
10. Expression of DDX3Y is detected in all myeloid and lymphoid leukemic cells that carry an intact Y chromosome. PMID: 18299450
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相關疾病：

DDX3Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia.
亞細胞定位：

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner.
蛋白家族：

DEAD box helicase family, DDX3/DED1 subfamily
組織特異性：

Widely expressed at the mRNA level, with highest levels in testis. Testis-specific (at protein level). Expressed predominantly in spermatogonia, but occasionally detected in some pre-leptotene/leptotene spermatocytes.
數據庫鏈接：

HGNC: 2699

OMIM: 400010

KEGG: hsa:8653

STRING: 9606.ENSP00000336725

UniGene: Hs.99120

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