DDX39A Antibody

說明書

中文名稱：

DDX39A兔多克隆抗體
貨號：

CSB-PA006620ESR2HU
規格：

￥440
圖片：
Western blot
All lanes: ATP-dependent RNA helicase DDX39A antibody at 2μg/ml
Lane 1: A431 whole cell lysate
Lane 2: 293T whole cell lysate
Lane 3: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 50, 37, 31 kDa
Observed band size: 50 kDa

Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA006620ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006620ESR2HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DDX39A Polyclonal antibody
Uniprot No.：

O00148
基因名：

DDX39A
別名：

DDX39A antibody; DDX39 antibody; ATP-dependent RNA helicase DDX39A antibody; EC 3.6.4.13 antibody; DEAD box protein 39 antibody; Nuclear RNA helicase URH49 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human ATP-dependent RNA helicase DDX39A protein (178-427AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus.
基因功能參考文獻：
1. DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation PMID: 28025139
2. DDX39A is a potential biomarker for unfavorable neuroblastoma PMID: 26469522
3. The protein levels of DDX39 were found to be higher in malignant pleural mesothelioma cell lines compared to normal pleural mesothelial cells. PMID: 23749908
4. Results suggest that DDX39 is a suppressor of invasion and loss of its function predicts disease progression in bladder cancers. PMID: 22494014
5. #NAME? PMID: 22119546
6. Requirement of DDX39 DEAD box RNA helicase for genome integrity and telomere protection PMID: 21388492
7. UAP56 and URH49 exhibit an intrinsic CRM1-independent nucleocytoplasmic shuttling PMID: 21799930
8. Mx proteins exert their antiviral activity against IAV by interfering with the function of the RNA helicases UAP56 and URH49 PMID: 21859714
9. Data show that the two closely related RNA helicases UAP56 and URH49 have evolved to form distinct mRNA export machineries, which regulate mitosis at different steps. PMID: 20573985
10. Using a UL69 viral mutant that is unable to bind UAP56 and URH49, the authors demonstrated that UL69's interaction with UAP56 or URH49 does not contribute to the growth phenotype associated with the UL69 deletion mutant. PMID: 20610707
11. Regulation of URH49 mRNA expression and comparison with the related UAP56 RNA helicase. PMID: 15047853
12. Reducing the expression of UAP56 and URH49 resulted in a reduction in reporter gene expression as well as cell death within 72 h suggest that both helicases have essential but largely overlapping functions in the processing and export of mammalian mRNAs. PMID: 16949217
13. CIP29 physically and functionally associates with DDX39, suggesting their cooperation in the RNA metabolism. PMID: 17196963
14. DDX39 is a novel RNA helicase capable of promoting cancer cell growth PMID: 17548965
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亞細胞定位：

Nucleus. Cytoplasm. Note=Can translocate to the cytoplasm in the presence of MX1.
蛋白家族：

DEAD box helicase family, DECD subfamily
組織特異性：

Detected in testis, and at lower levels in brain, kidney, lung, thymus, spleen and salivary gland.
數據庫鏈接：

HGNC: 17821

KEGG: hsa:10212

STRING: 9606.ENSP00000242776

UniGene: Hs.311609

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