DDI2 Antibody

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) DDI2 Polyclonal antibody
Uniprot No.：

Q5TDH0
基因名：

DDI2
別名：

DDI1 DNA damage inducible 1 homolog 2 antibody; Ddi2 antibody; DDI2_HUMAN antibody; DNA damage inducible 1 homolog 2 (S. cerevisiae) antibody; DNA damage inducible 1 homolog 2 antibody; DNA damage inducible protein 2 antibody; MGC14844 antibody; Protein DDI1 homolog 2 antibody; RP4-680D5.5 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Protein DDI1 homolog 2 protein (1-211AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，DDI2 Antibody (CSB-PA732937LA01HU)，的標(biāo)記方式是Non-conjugated。對于DDI2 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA732937LB01HU	DDI2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA732937LC01HU	DDI2 Antibody, FITC conjugated
Biotin	CSB-PA732937LD01HU	DDI2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane. Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1. Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity.
基因功能參考文獻(xiàn)：
1. the 3D structures of the human Ddi2 UBL and RVP domains were solved and identified a new helical domain that extends on either side of the Rretroviral protease-like dimer. PMID: 27461074
2. Here the authors show that the aspartyl protease DNA-damage inducible 1 homolog 2 (DDI2) is required to cleave and activate Nrf1. PMID: 27528193
亞細(xì)胞定位：

Cytoplasm, cytosol. Chromosome.
蛋白家族：

DDI1 family
數(shù)據(jù)庫鏈接：

HGNC: 24578

KEGG: hsa:84301

STRING: 9606.ENSP00000417748

UniGene: Hs.718857

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