D2HGDH Antibody
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中文名稱：D2HGDH兔多克隆抗體
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貨號：CSB-PA843153LA01HU
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規格：￥440
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圖片：
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Western Blot
Positive WB detected in: Mouse spleen tissue, Mouse brain tissue
All lanes: D2HGDH antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 57, 33, 35 kDa
Observed band size: 57 kDa
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) D2HGDH Polyclonal antibody
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Uniprot No.：
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基因名：D2HGDH
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別名：D2HGDH antibody; D2HGDD-2-hydroxyglutarate dehydrogenase antibody; mitochondrial antibody; EC 1.1.99.- antibody
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宿主：Rabbit
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反應種屬：Human, Mouse
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免疫原：Recombinant Human D-2-hydroxyglutarate dehydrogenase, mitochondrial protein (14-521AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，D2HGDH Antibody (CSB-PA843153LA01HU)，的標記方式是Non-conjugated。對于D2HGDH Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.
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基因功能參考文獻：
- D2HGDH-GAL3ST2 is more frequently seen in prostate cancer samples, and seems to be enriched in African Americans. PMID: 27322736
- D2HGDH elevates alpha-KG levels via IDH2 expression modulation, influencing histone and DNA methylation, and HIF1alpha hydroxylation. D2HGDH mutants found in diffuse large B-cell lymphoma are enzymatically inert. PMID: 26178471
- D2HGDH mutation is not associated with glioblastoma. PMID: 21625441
- We did not find evidence for mutations in the genes D2HGDH and L2HGDH as an alternative mechanism for raised 2-hydroxyglutarate levels in brain tumours PMID: 20727073
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20727073
- Two novel pathogenic mutations in D-2-hydroxyglutarate dehydrogenase gene in patient with a mild presentation and asymptomatic siblings with D-2-hydroxyglutaric aciduria with a splice error (IVS4-2A-->G) and a missense mutation (c.1315A-->G;p.Asn439Asp). PMID: 16037974
- This enzyme assay will have utility in differentiating patients with 2-hydroxyglutaric aciduria and in assessing the residual activities linked to pathogenic mutations in the D2HGDH gene PMID: 19283509
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相關疾病：D-2-hydroxyglutaric aciduria 1 (D2HGA1)
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亞細胞定位：Mitochondrion.
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蛋白家族：FAD-binding oxidoreductase/transferase type 4 family
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數據庫鏈接：
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