Cleaved-MMP15 (Y132) Antibody
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中文名稱：Cleaved-MMP15 (Y132)兔多克隆抗體
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貨號：CSB-PA000052
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規(guī)格：￥1090
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圖片：
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Western Blot analysis of COS7 cells using Cleaved-MMP-15 (Y132) Polyclonal Antibody
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：MMP15
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別名：MMP15; Matrix metalloproteinase-15; MMP-15; Membrane-type matrix metalloproteinase 2; MT-MMP 2; MTMMP2; Membrane-type-2 matrix metalloproteinase; MT2-MMP; MT2MMP; SMCP-2
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宿主：Rabbit
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反應(yīng)種屬：Human,Monkey
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免疫原：Synthesized peptide derived from the Internal region of Human MMP-15.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
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基因功能參考文獻(xiàn)：
- identify an MT2-MMP-E-cadherin axis that functions as a novel regulator of epithelial cell homeostasis in vivo PMID: 29061881
- Results suggest that MT2-MMP degrades adherens and tight junction proteins and results in EMT, making it a potential mediator of EMT in carcinomas. PMID: 27374080
- TCF-4 is a co-activator of NF-kappaB p65 that promotes MMP-15 transcription and potentiate the migration activity of the lung cancer cells PMID: 27046058
- In conclusion, MT2-MMP is involved in gastric cancer invasion and metastasis and may serve as an independent prognostic factor for gastric cancer patients. PMID: 25973093
- our data suggest that MT2-MMP expression positively involves in non-small cell lung cancer and might play an important role in promoting the tumor progression and intra-tumoral angiogenesis PMID: 25031779
- HLA-G expression involved in tumor invasiveness or metastasis may rely on the NK cytotoxicity inhibition and induction of MMP-15 expression in ovarian cancer. PMID: 23228395
- MMP-15 is up-regulated in preeclampsia, but does not cleave endoglin to produce soluble endoglin. PMID: 22768148
- MMP-15 and MMP-19 are upregulated during colorectal tumorigenesis PMID: 22576687
- Data show that MT2-MMP was a novel hypoxia-responsive gene and was upregulated by HIF-1alpha under hypoxia. PMID: 21751260
- The intensity of immunochemical staining of MT2-MMP was significantly positively correlated to the intratumoral angiogenesis of esophageal cancer tissues. PMID: 21036765
- MMP2 activity is associated with an increase in MT2-MMP expression and with lymph node metastasis. PMID: 20586027
- These results indicate MT2-MMP might be involved in the cancer progression more than or equal to MT1-MMP independently of MMP-2 and MT1-MMP. PMID: 20117087
- Data show that the MT2-MMP catalytic domain has a higher propensity than that of MT1-MMP to initiate cleavage of the MMP-2 prodomain in the absence of TIMP-2. PMID: 16825197
- Type-2 metalloproteinases, are identified as the triggering agents that independently confer cancer cells with the ability to proteolytically efface the BM scaffolding, initiate the assembly of invasive pseudopodia, and propagate transmigration. PMID: 16983145
- Data show that MMP15 may be relevant with carcinogenesis, development and metastasis of adenoid cystic carcinoma, and different metastasis potential may result from different subtype of MMPs gene family. PMID: 17029196
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亞細(xì)胞定位：Membrane; Single-pass type I membrane protein; Extracellular side.
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蛋白家族：Peptidase M10A family
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組織特異性：Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
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數(shù)據(jù)庫鏈接：
