Cleaved-ITIH4 (R661) Antibody

說明書

中文名稱：

Cleaved-ITIH4 (R661)兔多克隆抗體
貨號：

CSB-PA011276
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q14624
基因名：

ITIH4
別名：

35 kDa inter-alpha-trypsin inhibitor heavy chain H4 antibody; gp120 antibody; H4P antibody; IHRP antibody; Inter-alpha-inhibitor heavy chain 4 antibody; Inter-alpha-trypsin inhibitor family heavy chain-related protein antibody; Inter-alpha-trypsin inhibitor heavy chain H4 antibody; inter-alpha-trypsin inhibitor, heavy chain-like, 1 antibody; ITI heavy chain H4 antibody; ITI-HC4 antibody; ITIH4 antibody; ITIH4_HUMAN antibody; ITIHL1 antibody; OTTHUMP00000197120 antibody; OTTHUMP00000197121 antibody; OTTHUMP00000213834 antibody; OTTHUMP00000213869 antibody; PK-120 antibody; PK120 antibody; Plasma kallikrein sensitive glycoprotein 120 antibody; PRO1851 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human ITI-H4 70k.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:10000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.
基因功能參考文獻：
1. Low ITIH4 expression is associated with Hepatocellular Carcinoma. PMID: 28828637
2. this report has further supported for associations of genetic variants in the ITIH4 and CALN1 genes with schizophrenia and provided the first evidence that the variants regulate ITIH4 AND CALN1 expression in the dorsolateral prefrontal cortex PMID: 26991396
3. ITIH4 peptide isoform as a preterm birth biomarker and its associated SNP implications PMID: 26408095
4. Serum ITIH4 may be a PM10-specific biomarker in COPD and may be related to inflammation. PMID: 25977605
5. Four novel body mass index-associated loci near the KCNQ1(rs2237892), ALDH2/MYL2 (rs671, rs12229654), ITIH4 (rs2535633) and NT5C2 (rs11191580) genes are identified in East Asian-ancestry populations. PMID: 24861553
6. Worse survival among HCC patients with low ITIH4. PMID: 24836184
7. Isoform-specific ITIH4 glycosylation and utilization of O-glycosylation sites on ITIH4 differs between cell lines and serum. PMID: 24884609
8. Expression of the 85 kDa ITIH4 was substantial in amyotrophic lateral sclerosis compared with controls or patients with muscular dystrophy, Alzheimer diseases, or Parkinson diseases PMID: 23436019
9. A truncated fragment of inter-alpha-trypsin inhibitor heavy chain 4 was the sole protein found to be significantly enhanced in the prostate cancer patients compared to the controls. PMID: 23417432
10. Findings suggest that ITI-H4 expression may be used as a biomarker, which could facilitate the development of novel diagnostic and therapeutic tools. PMID: 21331437
11. Genetic variation at ITIH4 locus is one of the likely candidate determinants for plasma cholesterol metabolisms PMID: 14661079
12. ITIH4 and MTJ1 co-immunoprecipitate from total liver protein extracts and SANT domain of HTJ1 protects the ITIH4(588-930) recombinant fragment PMID: 16271702
13. The inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) protein was significantly present more in interstial cystitis than controls PMID: 18455532
14. ITIH4 is an anti-inflammatory protein, and suggests that further investigation into its potential use in the diagnosis and prognosis of acute ischemic stroke is warranted. PMID: 19263524
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亞細胞定位：

Secreted.
蛋白家族：

ITIH family
組織特異性：

Liver specific.
數據庫鏈接：

HGNC: 6169

OMIM: 600564

KEGG: hsa:3700

STRING: 9606.ENSP00000266041

UniGene: Hs.709406

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