Casp12 Antibody

中文名稱：

Casp12兔多克隆抗體
貨號：

CSB-PA004545LA01MO
規格：

￥440
圖片：
Western blot
All lanes: Casp12 antibody at 6µg/ml + LO2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 48 kDa
Observed band size: 48, 75 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Mus musculus (Mouse) Casp12 Polyclonal antibody
Uniprot No.：

O08736
基因名：

Casp12
別名：

Casp12Caspase-12 antibody; CASP-12 antibody; EC 3.4.22.- antibody
宿主：

Rabbit
反應種屬：

Mouse, Human
免疫原：

Recombinant Mouse Caspase-12 protein (1-92AA)
免疫原種屬：

Mus musculus (Mouse)

標記方式：

Non-conjugated

本頁面中的產品，Casp12 Antibody (CSB-PA004545LA01MO)，的標記方式是Non-conjugated。對于Casp12 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA004545LB01MO	Casp12 Antibody, HRP conjugated	ELISA
FITC	CSB-PA004545LC01MO	Casp12 Antibody, FITC conjugated
Biotin	CSB-PA004545LD01MO	Casp12 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in the activation cascade of caspases responsible for apoptosis execution.
基因功能參考文獻：
1. mice ablated for caspase-12 develop spontaneous obesity and insulin resistance. PMID: 26582949
2. Caspase-12 plays a pivotal role in CCl4-induced hepatic apoptosis through the activation of the downstream effector caspase-3 directly and/or indirectly via caspase-9 activation. PMID: 25561786
3. We validated caspase-12 as a therapeutic target, ablation of which significantly protects T17M photoreceptors from deterioration. PMID: 26207309
4. Findings an increase in multiple unfolded protein response pathways in muscles of the dystrophin-deficient mdx mouse, the model for Duchenne muscular dystrophy. PMID: 24879640
5. Tauroursodeoxycholic acid intervention down-regulated GRP78 and CHOP expression and Caspase 12 activation. PMID: 22212133
6. Findings indicate that although caspase-12 deficiency results in enhanced pro-inflammatory and immunoregulatory cytokine levels in sera during P. yoelii 17XL infection, these responses are not essential for protection against lethal malaria infection. PMID: 21086719
7. caspase-12 competed with NEMO for association with IkappaB kinase-alpha/beta, effectively preventing the formation of the IkappaB kinase complex and inhibiting downstream transcriptional activation by NF-kappaB. PMID: 20876354
8. Caspase-12 was required for an effective antiviral immune response, especially for the production of type I interferons through the regulation of TRIM25-mediated ubiquitination of RIG-I. . PMID: 20818395
9. Matrix metalloproteinase-3 is increased and participates in neuronal apoptotic signaling downstream of caspase-12 during endoplasmic reticulum stress PMID: 20368330
10. Reactive oxygen species promote caspase-12 expression and tubular apoptosis in diabetic nephropathy. PMID: 20299359
11. enhanced repair response of Casp12(-/-) mice rendered them more susceptible to colorectal cancer induced by azoxymethane (AOM)+ dextran sulfate sodium. PMID: 20226691
12. role of caspase-12-dependent pathway in apoptosis induction by manganese(II) PMID: 11964391
13. caspase-12 was activated by poly(Q)(72) aggregates via a pathway independent of caspase-8 and caspase-3 activation, and caspase-12 activation was closely associated with poly(Q) aggregate-mediated cell death PMID: 12045204
14. procaspase-9 is a substrate of caspase-12 and ER stress triggers a specific cascade involving caspase-12, -9, and -3 in a cytochrome c-independent manner. PMID: 12097332
15. Caspase-12 seems to be involved in neuronal death induced by ischemia/reperfusion. PMID: 12699784
16. Pathways involving this enzyme are involved in a neurodegenerative disease in vivo, and thus offer novel potential targets for the treatment of prion disorders. PMID: 14532116
17. caspase-12 expression in caspase-12 is regulated by NF-E2 and participates in the development of fully functional signaling pathways linking some G-protein-coupled receptors to alphaIIbbeta3 activation. PMID: 15059849
18. both caspases and calpains are involved in 661W photoreceptor apoptosis PMID: 15210718
19. The results indicate that oxidative and ER induced stress causing caspase-12 activation are involved in neuronal death and disease progression in ALS. PMID: 15313203
20. cloning of promoter PMID: 15701691
21. caspase-12 and caspase-4 are not required for the induction of ER stress-induced apoptosis and that caspase-4-like activity is not always associated with an initiating event. PMID: 15975932
22. Ribozyme 138 prepared in vitro can site specific cleave mouse caspase-12 mRNA with an excellent efficiency. PMID: 15996037
23. Data show that overexpression of X-linked Inhibitor of Apoptosis Protein (XIAP)inhibits caspase-12 cleavage and reduces calpain activity in amyotrophic lateral sclerosis mice. PMID: 16566922
24. provides compelling genetic evidence for calpain's role in caspase-12 activation at the endoplasmic reticulum (ER), and reveals a novel role for the ubiquitous calpains in ER-stress induced apoptosis and JNK activation PMID: 16597616
25. In mice, caspase-12 deficiency confers resistance to sepsis and its presence exerts a dominant-negative suppressive effect on caspase-1, resulting in enhanced vulnerability to bacterial infection and septic mortality PMID: 16625199
26. apoptosis-inducing factor plays the major role in this apoptotic event, whereas caspase-12 has a reinforcing effect PMID: 17088543
27. Data show that caspase-12 can compensate for lack of caspase-2 and caspase-3 in female germ cells. PMID: 17245644
28. In hippocampal neuroblasts, Ca(++) mobilization from ER and caspase-12 activation are components of the molecular pathway that leads to apoptosis triggered by serum deprivation and may constitute an amplifying loop of the mitochondrial pathway. PMID: 17399692
29. Nod activation and resulting antimicrobial peptide production constitute an early innate defense mechanism, and caspase-12 inhibits this mucosal antimicrobial response. PMID: 18329614
30. caspase-12 is not necessary for mediating the neurotoxic effects of prion protein misfolding. PMID: 19164919
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蛋白家族：

Peptidase C14A family
組織特異性：

Mainly expressed in skeletal muscle and lung.
數據庫鏈接：

KEGG: mmu:12364

STRING: 10090.ENSMUSP00000027009

UniGene: Mm.42163

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