Capsid protein VP1 Antibody, Biotin conjugated

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說明書

產品詳情

產品名稱：

Rabbit anti-Human parvovirus B19 N/A Polyclonal antibody
Uniprot No.：

P07299
基因名：

N/A
別名：

Minor capsid protein VP1 antibody; EC 3.1.1.4 antibody; Coat protein VP1 antibody
宿主：

Rabbit
反應種屬：

Human parvovirus B19
免疫原：

Recombinant Human parvovirus B19 Capsid protein VP2 protein (228-781AA)
免疫原種屬：

Human parvovirus B19
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 20 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Binds to erythroid progenitor cells expressing high levels of P antigen and uses host ITGA5-ITGB1 and XRCC5/Ku80 autoantigen as coreceptors on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region. The additional N-terminal region of isoform Minor capsid protein VP1, called VP1u, may serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.
亞細胞定位：

[Isoform Minor capsid protein VP1]: Virion. Host nucleus. Host cytoplasm.; [Isoform Major capsid protein VP2]: Virion. Host nucleus. Host cytoplasm.
蛋白家族：

Parvoviridae capsid protein family

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