CXXC5 Antibody

中文名稱：

CXXC5兔多克隆抗體
貨號：

CSB-PA741975LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA741975LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA741975LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) CXXC5 Polyclonal antibody
Uniprot No.：

Q7LFL8
基因名：

CXXC5
別名：

CF5 antibody; CXXC finger 5 protein antibody; CXXC finger protein 5 antibody; CXXC-type zinc finger protein 5 antibody; CXXC5 antibody; CXXC5_HUMAN antibody; HSPC195 antibody; Putative MAPK-activating protein PM08 antibody; Putative NF-kappa-B-activating protein 102 antibody; retinoid-inducible nuclear factor antibody; RINF antibody; TCCCIA00297 antibody; WID antibody; WT1-induced Inhibitor of Dishevelled antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human CXXC-type zinc finger protein 5 protein (1-227AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，CXXC5 Antibody (CSB-PA741975LA01HU)，的標記方式是Non-conjugated。對于CXXC5 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應用
HRP	CSB-PA741975LB01HU	CXXC5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA741975LC01HU	CXXC5 Antibody, FITC conjugated
Biotin	CSB-PA741975LD01HU	CXXC5 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ. Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG.
基因功能參考文獻：
1. show here that CXXC5 is an E2-ERalpha responsive gene regulated by the interaction of E2-ERalpha with an ERE present at a region upstream of the initial translation codon of the gene PMID: 27886276
2. High CXXC5 expression seems to affect several steps in human leukemogenesis, including intracellular events as well as extracellular communication. PMID: 25605239
3. Findings suggest that overexpression of CXXC5 in C2C12 myoblasts facilitated myocyte differentiation, while RNAi interference of CXXC5 significantly inhibited the differentiation of C2C12 myoblasts. PMID: 25433557
4. Low CXXC5 expression is associated with acute myeloid leukemia. PMID: 25805812
5. targeting of CXXC5/RINF should be considered as a possible therapeutic strategy, especially in high-risk patients who show increased expression in AML cells compared with normal hematopoietic cells PMID: 23988457
6. Lack of promoter hypermethylation or somatic mutations are found in the potential tumor suppressor CXXC5 in myelodysplastic syndromes or acute myeloid leukemia with deletion 5q. PMID: 23190153
7. RINF overexpression represents an independent molecular marker for poor prognosis in breast tumors. PMID: 21325450
8. RINF expression correlates with retinoid-induced differentiation of leukemic cells and with cytokine-induced myelopoiesis of normal CD34(+) progenitors. PMID: 19182210
9. These findings suggest that CF5 plays a crucial role in ATM-p53 signaling in response to DNA damage. PMID: 19557330
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亞細胞定位：

Nucleus. Cytoplasm.
數(shù)據(jù)庫鏈接：

HGNC: 26943

OMIM: 612752

KEGG: hsa:51523

STRING: 9606.ENSP00000302543

UniGene: Hs.189119

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