CXXC1 Antibody

說明書

中文名稱：

CXXC1兔多克隆抗體
貨號：

CSB-PA868380DSR2HU
規格：

￥440
圖片：
Western blot
All lanes: CXXC-type zinc finger protein 1 antibody at 2μg/ml
Lane 1: THP-1 whole cell lysate
Lane 2: Mouse liver tissue
Lane 2: Mouse spleen tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 76, 77 kDa
Observed band size: 76 kDa

Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA868380DSR2HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CXXC1 Polyclonal antibody
Uniprot No.：

Q9P0U4
基因名：

CXXC1
別名：

2410002I16Rik antibody; 5830420C16Rik antibody; AI426635 antibody; CFP 1 antibody; CFP1 antibody; CpG binding protein antibody; CpG-binding protein antibody; CXXC 1 antibody; CXXC finger 1 antibody; CXXC finger 1 PHD domain antibody; CXXC finger protein 1 antibody; CXXC type zinc finger protein 1 antibody; CXXC-type zinc finger protein 1 antibody; CXXC1 antibody; CXXC1_HUMAN antibody; DNA binding protein with PHD finger and CXXC domain antibody; hCGBP antibody; HsT2645 antibody; PCCX 1 antibody; PCCX1 antibody; PHD finger and CXXC domain containing protein 1 antibody; PHD finger and CXXC domain-containing protein 1 antibody; PHF 18 antibody; PHF18 antibody; Protein containing CXXC domain 1 antibody; SPP 1 antibody; SPP1 antibody; ZCGPC 1 antibody; ZCGPC1 antibody; Zinc finger; CpG binding type containing 1 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human CXXC-type zinc finger protein 1 protein (1-210AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.
基因功能參考文獻：
1. CFP1 binds open chromatin regions of active genes, including enhancers and non-CpG islands. PMID: 30292235
2. directly controls the expression of key genes important for thymocyte survival, such as RORgammat, and for T-cell receptor signaling, including Zap70 and CD8, through maintaining the appropriate H3K4me3 on their promoters PMID: 27210293
3. NF-kappaB recruitment enhanced the occupancy of the CpG island within the 14-3-3gamma promoter by CFP1.14-3-3gamma induction in CSR is enabled by the CFP1-mediated H3K4me3 enrichment in the promoter, dependent on NF-kappaB and sustained by E2A. PMID: 23851690
4. The crescent-shaped CFP1 CXXC domain is wedged into the major groove of the CpG DNA, distorting the B-form DNA, and interacts extensively with the major groove of the DNA. PMID: 21407193
5. CXXC finger protein 1 is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex PMID: 16253997
6. CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line. PMID: 17328666
7. CGBP interacts with MLL1, MLL2 as well as Set1 H3-Lysine 4 (H3K4) specific methyl-transferases and plays critical roles in regulations of MLL target genes. PMID: 18082152
8. study shows endogenous DNMT1 & CFP1 interact in vivo; CFP1 interaction with Setd1A or Setd1B not required for its interaction with DNMT1; result indicates CFP1 intersects cytosine methylation machinery independently of its association with Setd1 complexes PMID: 18680430
9. expression of either the amino half of Cfp1 (amino acids 1 to 367 [Cfp1(1-367)]) or the carboxyl half of Cfp1 (Cfp1(361-656)) is sufficient to correct all of the defects observed with embryonic stem cells that lack Cfp1 PMID: 19433449
顯示更多

收起更多
亞細胞定位：

Nucleus speckle. Nucleus. Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes.
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 24343

OMIM: 609150

KEGG: hsa:30827

STRING: 9606.ENSP00000390475

UniGene: Hs.180933

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human