CSPP1 Antibody
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中文名稱：CSPP1兔多克隆抗體
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貨號：CSB-PA635936DSR2HU
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規格：￥440
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圖片：
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Western blot
All lanes: CSPP1 antibody at 1.53 μg/ml
Lane 1: 293T whole cell lysate
Lane 2: Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 146, 142, 102 kDa
Observed band size: 146, 75, 55 kDa -
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA635936DSR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CSPP1 Polyclonal antibody
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Uniprot No.：
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基因名：CSPP1
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別名：CSPP1 antibody; CSPPCentrosome and spindle pole-associated protein 1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Centrosome and spindle pole-associated protein 1 protein (997-1256AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May play a role in cell-cycle-dependent microtubule organization.
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基因功能參考文獻：
- Microtubule-independent but desmoplakin-dependent localization of CSPP-L to desmosomes occurs in apical-basal polarized epithelial cells. CSPP-L depletion promoted multi-lumen spheroid formation in Caco-2 cells. PMID: 26241740
- Differential expression of a nuclear CSPP1 isoform identified biologically and clinically distinct subgroups of basal-like breast carcinoma. PMID: 24901235
- mutations in CSPP1 were associated with variable ciliopathy phenotypes ranging from Joubert syndrome to the more severe Meckel-Gruber syndrome with perinatal lethality and occipital encephalocele PMID: 24360803
- Our data suggest that CSPP1 is required for proper primary cilium formation or stability and that CSPP1 mutations result in abnormal mid-hindbrain development. PMID: 24360807
- CSPP1 mutations are a major cause of the Joubert-Jeune phenotype in humans. PMID: 24360808
- CSPP isoforms require their common C-terminal domain to interact with Nephrocystin 8 (NPHP8/RPGRIP1L) and to form a ternary complex with NPHP8 and NPHP4. PMID: 20519441
- Novel centrosome/microtubule-associated coiled-coil protein (CSPP)is associated with centrosomes and microtubules and may play a role in the regulation of G(1)/S-phase progression and spindle assembly [CSPP]. PMID: 15580290
- Taken together, CSPP and CSPP-L interact with centrosomes and microtubules and can differently affect microtubule organization. PMID: 16826565
- Taken together, CSPP and CSPP-L interact with centrosomes and microtubules and can differently affect microtubule organization.[CSPP-L] PMID: 16826565
- CSPP interacts with and recruits MyoGEF to the central spindle, where MyoGEF contributes to the spatiotemporal regulation of cytokinesis. PMID: 19129481
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相關疾病：Joubert syndrome 21 (JBTS21)
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亞細胞定位：Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Associated with mitotic spindles.
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組織特異性：Expressed in adult and fetal brain with enrichment in the cerebellum. Detected in testis.
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數據庫鏈接：
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