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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
基因功能參考文獻(xiàn):
Study indicated that MTHFR rs1801133, FGF5 rs16998073 and CSK rs1378942 were associated with increased the risk of obesity in the Chinese children. PMID: 30217759
These results identified a novel role for Csk as a host tyrosine kinase involved in dengue virus replication. PMID: 27457684
Domain interactions of C-terminal Src Kinase determined through NMR spectroscopy with segmental isotope labeling PMID: 27815825
Data suggest that myristoylation of Src kinase is essential to facilitate Src-induced and high-fat diet-accelerated prostatic tumor progression; targeting Src kinase myristoylation, which is required for Src kinase association at cellular membrane, blocks dietary fat-accelerated tumorigenesis. PMID: 28939770
Linear mixed-effect regressions showed significant association between rs1378942 in CSK and systolic blood pressure (beta = 0.98+/-0.46, P = 3.4x10-2). The child genotype scores for diastolic and systolic blood pressure were not associated in children. PMID: 29045471
H2O2-induced Csk translocation to the plasma membrane leads to phosphorylation of Src at the tyrosine 530 residue resulting in a reduction of ERK1/2 phosphorylation. PMID: 26234813
Data suggest that as a natural inhibitor of c-Src kinase, naringin could be an effective candidate for the treatment of melanoma. PMID: 26476533
deregulation of the Pragmin-Csk axis may induce aberrant cell migration that contributes to tumor invasion and metastasis PMID: 27116701
Our results do not support association between PTPN22/CSK and Henoch-Schonlein purpura PMID: 26458874
Results identify CSK downregulation as a principal driver of SRC activation and castration resistance. PMID: 26091350
Variant rs1378942 near CSK was nominally associated with systolic blood pressure in a Chinese population. PMID: 25618516
CSK is the kinase responsible for C-terminal phosphorylation of SRC, but not BRK. PMID: 25897081
Data indicate that the potent c-Src inhibitors pyrazolo[3,4-d]pyrimidines showed in vivo activity in neuroblastoma xenograft model. PMID: 25469771
Haemophilus ducreyi LspA1 protein inhibits phagocytosis by activation of host CSK. PMID: 24902122
In Chinese children, no association of CSK rs1378942, MTHFR rs1801133, CYP17A1 rs1004467, STK39 rs3754777 and FGF5 rs16998073 with BP/risk of hypertension. PMID: 23759979
the activity of SIRT2 is regulated by c-Src through post-translational modifications. PMID: 24996174
Data indicate that the accumulation of the cleaved C-terminal small fragment of eukaryotic elongation factor 2 (eEF2) in the nucleus, and C-terminal Src kinase (Csk) could enhance the proteolytic cleavage of eEF2. PMID: 24648518
alpha6beta4 integrin and c-Src activation is important early signaling events to lead mTOR activation and cap-dependent translation of VEGF. PMID: 24180592
Induction of stem cell differentiation alters regulation of FAK and Src activities. PMID: 24015220
JAM-A recruits Csk to the integrin-c-Src complex, where Csk negatively regulates c-Src activation, thereby suppressing the initiation of outside-in signaling. PMID: 24300854
In summary, the free-energy landscape calculations demonstrate that phosphorylation of tyrosine 416 in the A-loop essentially "locks" the kinase into its catalytically competent conformation. PMID: 24103328
An appreciable amount of Y416 was phosphorylated when c-Src was in a closed, repressed conformation under conditions by which c-Src was unable to phosphorylate substrate STAT3. PMID: 23923048
We also unveiled a possible mechanistic link between ASPP2 and Csk/Src signaling pathway, implicating the multiple cellular functions of ASPP2. PMID: 23671128
rs1378942 and rs34933034 variants were not significantly associated with giant cell arteritis. PMID: 23946333
High C-terminal Src kinase expression is associated with colorectal cancer. PMID: 23824743
Ca2+ sparklet activity is promoted by the action of c-Src on tyrosine2122 residue of the Cav1.2c COOH terminus. PMID: 23804206
detailed study of LYP/CSK interaction, here presented, showed that LYP/CSK interaction was inducible upon TCR stimulation, and involved LYP P1 and P2 motifs, and CSK SH3 and SH2 do PMID: 23359562
p140Cap phosphorylation sites and binding to Csk and Abl kinase PMID: 23383002
No significant association was observed for CSK rs1378942 or MTHFR rs17367504 and hypertension in East Asians. PMID: 22959498
This suggests that the Lyp-Csk complex increases susceptibility to lupus at multiple maturation and activation points in B cells. PMID: 23042117
these results indicate that thrombin might activate c-Src to induce JAK2 activation, which in turn, causes STAT3 activation, and finally induces CCN2 expression in human lung fibroblasts. PMID: 23108098
Data provide evidence for replication and overall genome-wide significance for systemic sclerosis (SSc) genetic risk locus: tyrosine-protein kinase CSK with P-value = 5.04 x 10(-12), odds ratio (OR) = 1.20. PMID: 22407130
the association between Furin and its substrate MT1-MMP is regulated by PDGFR stimulation and c-Src. PMID: 22038627
These findings suggest that 25-methoxyhispidol A-mediated inhibitory activity of human breast cancer cell growth might be related with the cell cycle arrest and modulation of signal transduction pathways. PMID: 21782877
c-Src regulates nuclear factor kappa B signaling by targeting NEMO PMID: 21538482
PTPIP51 is phosphorylated by Lyn and c-Src kinases lacking dephosphorylation by PTP1B in acute myeloid leukemia. PMID: 21513978
c-Src signals through protein kinase Calpha, phospholipase Cgamma, and LKB1 to AMPK. AMPK controls internal ribosome entry site (IRES) dependent translation in these cells PMID: 21245141
The ROS-c-Src kinase-mTOR pathway played a central role in the signaling pathway that linked albumin to epithelial mesenchynal transition and endoplasmic reticular stress. PMID: 21367918
Results indicate that Cbp is required for the Csk-mediated inactivation of c-Src and may control the promotion of malignancy in NSCLC tumors that are characterized by c-Src upregulation. PMID: 21156787
Data demonstrate the prognostic role of phospho-Src family kinase in tongue cancer in an inverse correlation between phospho-Src family kinase and patient survival. PMID: 19565264
Cloning of the complete coding sequence of the cDNA of the Csk and Yes tyrosine kinases genes of the human lymphocytes and retina have been carried out. PMID: 19757166
Consistent genetic factors for ATP2B1, CSK, ARSG and CSMD1 were present, which have been shown to be associated with high blood pressure and hypertension in two Korean cohorts. PMID: 19960030
the SH2-domain-mediated activation of Csk is dependent on the binding of the beta3-alphaC loop Ala228 to the hydrophobic pocket formed by the side chains of Tyr116, Tyr133, Leu138, and Leu149 on the surface of the SH2 domain PMID: 20434462
A sublethal dose of myoglobin (100 microg/ml) induced VCAM-1 expression via activation of AP-1 and NF-kappaB, which was mediated through activation of c-Src kinase PMID: 19887846
Csk mis-localization defines a novel mechanism for SFK oncogenic activation in CRC cells. PMID: 20010872
tyrosine kinase Csk dimerizes through Its SH3 domain PMID: 19888460
NMR and site-directed mutagenesis reveal novel mechanism of enzyme regulation PMID: 11724538
Regulation of an ERG K+ current by Src tyrosine kinase. PMID: 11834728
Tyrosine kinase c-Src constitutes a bridge between cystic fibrosis transmembrane regulator channel failure and MUC1 overexpression in cystic fibrosis PMID: 11872746