CRYGC Antibody
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中文名稱：CRYGC兔多克隆抗體
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貨號：CSB-PA006019GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：CRYGC
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別名：CATARACT; VARIABLE ZONULAR PULVERULENT antibody; CCL antibody; CRGC_HUMAN antibody; CRYG 3 antibody; Cryg 5 antibody; Cryg antibody; CRYG3 antibody; CRYGC antibody; Crystallin gamma 3 antibody; Crystallin gamma C antibody; Gamma C crystallin antibody; Gamma crystallin 2 1 antibody; Gamma crystallin 3 antibody; Gamma crystallin C antibody; Gamma-C-crystallin antibody; Gamma-crystallin 2-1 antibody; Gamma-crystallin 3 antibody; Gamma-crystallin C antibody; Gammab cry antibody; Len antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human CRYGC
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Crystallins are the dominant structural components of the vertebrate eye lens.
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基因功能參考文獻：
- Study identified eight different mutations in CRYGC associated with autosomal dominant congenital nuclear cataracts (ADCC) in a cohort of Chinese family and shows that CRYGC mutations are responsible for 4.1% of ADCC families in the cohort. The results expand the spectrum of CRYGC mutations as well as their associated phenotypes. PMID: 28298635
- the G129C mutation in gammaC-crystallin, which is associated with autosomal dominant congenital nuclear cataract, perturbed the unfolding process by promoting the accumulation of two distinct aggregation-prone intermediates under mild denaturing conditions. PMID: 26165230
- Exome sequencing in developmental eye disease leads to identification of causal variants in GJA8, CRYGC, PAX6 and CYP1B1. PMID: 24281366
- We confirm that congenital cataract is associated with a CRYGC gene mutation. PMID: 23954869
- identified a CRYAA mutation in family A and a CRYGC mutation in family B with congenital cataract PMID: 23441109
- A nonsense mutation c.471G>A in CRYGC is associated with autosomal dominant congenital nuclear cataracts and microcornea in a Chinese pedigree. PMID: 22876111
- Molecular modeling and spectroscopic studies indicated that the mutation impaired the tertiary structure of gamma C crystallin by modifying the H-bonding network in the C-terminal domain. PMID: 22052681
- Transgenic expression of mutant CRYGC5bpd gamma-crystallin at near-physiological levels causes lens opacities and fiber cell defects, confirming the pathogenicity of this mutation. PMID: 21436266
- The T5P mutation obviously changes conformation and decreases conformational stability. PMID: 11904153
- the loss of interactions of T5P mutant of the gammaC-crystallin with other crystallins may play a larger role than the protection afforded by chaperone-like activity in Coppock-like cataract. PMID: 15322286
- This is the first case of phenotypic heterogeneity in the primary congenital cataract specifically associated with the R168W mutation in the CRYGC gene. PMID: 17679936
- Identification of a novel nonsense mutation in CRYGC in a Chinese family with autosomal dominant congenital nuclear cataracts and microcornea. PMID: 19204787
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相關疾病：Cataract 2, multiple types (CTRCT2)
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蛋白家族：Beta/gamma-crystallin family
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數據庫鏈接：
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