CRTC2 Antibody

說明書

中文名稱：

CRTC2兔多克隆抗體
貨號：

CSB-PA832743
規格：

￥1100
圖片：
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Raji cells, Primary antibody: CSB-PA832743(CRTC2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q53ET0
基因名：

CRTC2
別名：

CREB regulated transcription coactivator 2 antibody; CREB-regulated transcription coactivator 2 antibody; CRTC2 antibody; CRTC2_HUMAN antibody; RP11-422P24.6 antibody; TORC-2 antibody; torc2 antibody; Transducer of CREB protein 2 antibody; Transducer of regulated cAMP response element-binding protein antibody; Transducer of regulated cAMP response element-binding protein (CREB) 2 antibody; Transducer of regulated cAMP response element-binding protein 2 antibody; Transducer of regulated CREB protein 2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human CRTC2
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
基因功能參考文獻：
1. Study suggests that Creb/Crtc2 negatively regulates the Sirt1/Pparalpha/Fgf21 axis via the induction of miR-34a under diet-induced obesity and insulin-resistant conditions. PMID: 29192248
2. Thyroid stimulating hormone activates CRTC2 via the TSHR/cAMP/PKA pathway. PMID: 28212844
3. CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in transplant recipients after solid organ transplantation. PMID: 26644205
4. CRTC2 strongly enhances GR-induced transcriptional activity of glucocorticoid-responsive genes. PMID: 26652733
5. Our results establish a role for CRTC2 as a lymphoma tumor suppressor gene PMID: 26004186
6. the high expression of CRTC2 and PROM1 may play an important role in the occurrence and hereditary, and also advance the potential pathways that integrate genetic variants in the development of NSCLC. PMID: 25256670
7. The data from the current study demonstrated novel PROM1 and CRTC2 mutations, which could promote lung cancer development. PMID: 24484648
8. These results clearly indicate that non-phosphorylated CRTC2 strongly enhances hepatitis b virus biosynthesis through inducing PGC1alpha expression. PMID: 24529027
9. Phosphorylation of CRTC2 at its AMPK target site, Ser 171, dictated its subcellular localization, and the activation of aromatase PII in preadipocytes. PMID: 23584792
10. CRTC2 enhances CREB phosphorylation through an association with the protein arginine methyltransferase 5 (PRMT5). PMID: 23671120
11. Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2 PMID: 23213254
12. The lipogenic effects of GIP in the presence of insulin are therefore at least partially mediated by upregulation of adipocyte LPL gene transcription through a pathway involving PI3-K/PKB/AMPK-dependent CREB/TORC2 activation. PMID: 20693566
13. the association of Pin1 with CRTC2 to decrease the nuclear CBP.CRTC.CREB complex. PMID: 20675384
14. Tax binds the cyclin D1 promoter-proximal cyclic AMP response element (CRE) in the presence of phosphorylated CREB (pCREB) in vitro, and together the Tax-pCREB complex recruits the cellular co-activator p300 to the promoter. PMID: 20101207
15. Thus, both TORC1/2 and p300 families of coactivators are essential for optimal activation of HTLV-1 transcription by Tax. PMID: 16809310
16. latent cytoplasmic coactivator TORC2 mediates target gene activation in response to cAMP signaling by associating with CBP/p300 and increasing its recruitment to a subset of CREB target genes PMID: 17476304
17. TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation. PMID: 17548807
18. genetic variants of LKB1-AMPK-TORC2 pathway components may exert a weak influence on the occurrence of type 2 diabetes in Japanese PMID: 17950019
19. identify Ser-275 of TORC2 as a 14-3-3 binding site that is phosphorylated under low glucose conditions and which becomes dephosphorylated by calcineurin in response to glucose influx PMID: 18626018
20. TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein. PMID: 19164291
21. The regulation of aromatase by CRTC2, in response to the altered hormonal milieu associated with menopause and obesity, provides a critical link between obesity and breast cancer. PMID: 19509226
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

TORC family
組織特異性：

Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, hear
數據庫鏈接：

HGNC: 27301

OMIM: 608972

KEGG: hsa:200186

STRING: 9606.ENSP00000357622

UniGene: Hs.406392

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