CRTAP Antibody
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中文名稱：CRTAP兔多克隆抗體
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貨號：CSB-PA005999ESR2HU
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規格：￥440
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圖片：
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Western blot
All lanes: CRTAP antibody at 0.96µg/ml
Lane 1: 293T whole cell lysate
Lane 2: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 47 kDa
Observed band size: 47 kDa -
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA005999ESR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA005999ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CRTAP Polyclonal antibody
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Uniprot No.：
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基因名：CRTAP
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別名：CRTAP antibody; CASPCartilage-associated protein antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Cartilage-associated protein (20-240AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.
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基因功能參考文獻：
- To the best of our knowledge, our study is the first to exclude potential correlations between heterozygous variants in CRTAP and milder skeletal impairments in a large number of patients PMID: 27901313
- This study enhances our knowledge about the mutational pattern of the LEPRE1, CRTAP, and PPIB genes. LEPRE1 should be the first gene analyzed in mutation detection studies in patients with recessive OI. PMID: 26634552
- An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro. PMID: 24043621
- SNP rs7623768 and the haplotype G-C of rs4076086-rs7623768 in CRTAP were associated with femoral neck bone mineral density (p = 0.009 and p = 0.003, respectively). PMID: 19727905
- Importantly, human mutations in the CRTAP gene have been associated with recessive forms of OI. PMID: 20425614
- CRTAP deficiency results in higher bone mineral content of the bone matrix in osteogenesis imperfecta type VII. PMID: 19895918
- Null mutations in LEPRE1 and CRTAP cause severe recessive osteogenesis imperfecta. PMID: 19862557
- CRTAP and P3H1 are mutually stabilized in the collagen prolyl 3-hydroxylation complex in endoplasmic reticulum. PMID: 19846465
- CRTAP mutations not described earlier were identified in 10 individuals who had a clinical diagnosis of lethal and severe osteogenesis imperfecta. PMID: 19550437
- complexes with prolyl 3-hydroxylase 1 (P3H1) to decrease prolyl 3 hydroxylation; dysregulation of prolyl 3 hydroxylation is a mechanism for connective tissue disease PMID: 17055431
- Screening of 78 subjects diagnosed with osteogenesis imperfecta type II or III, identified three probands with mutations in CRTAP and 16 with mutations in LEPRE1. PMID: 18566967
- Mutations in CRTAP and LEPRE1 are found in 3 patients with type II osteogenesis imperfecta. PMID: 18996919
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相關疾病：Osteogenesis imperfecta 7 (OI7)
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亞細胞定位：Secreted, extracellular space, extracellular matrix.
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蛋白家族：Leprecan family
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組織特異性：Found in articular chondrocytes. Expressed in a variety of tissues.
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數據庫鏈接：
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