CRLS1 Antibody
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中文名稱：CRLS1兔多克隆抗體
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貨號：CSB-PA005985GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：CRLS1
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別名：CRLS1; C20orf155; CLS1; Cardiolipin synthase; CMP-forming; CLS; Protein GCD10 homolog
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Human CRLS1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.
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基因功能參考文獻：
- Knockdown of human CRLS1 leads to a cardiolipin decrease, phosphatidylglycerol accumulation and mitochondrial elongation. PMID: 29251771
- transgenic expression of cardiolipin synthase attenuated maladaptive cardiolipin remodeling and bioenergetic inefficiency in myocardium rendered diabetic by streptozotocin treatment. PMID: 22584571
- CLS mRNA levels cannot be correlated with CLS enzyme activity nor CL content in the LPS model of inflammation. PMID: 20652826
- A human candidate gene/cDNA for cardiolipin synthase, C20orf155, was identified. PMID: 16678169
- hCLS1 protein was localized to the mitochondria when transiently expressed in COS-7 cells PMID: 16716149
- We describe here a human gene for CLS and its analysis via RNAi knockdown on apoptotic progression. PMID: 16888643
- anti-cardiolipin antibody positivity is an independent predictor of chronic renal failure PMID: 19048414
- Patients with solid and non-solid malignancies display anticardiolipin antibodies associated with increased rate of thrombosis PMID: 19048416
- presence of cardiolipin autoantibodies is criteria for diagnostics of antiphospholipid syndrome PMID: 19052923
- associated with Libman-Sacks endocarditis, cardiac manifestation of SLE PMID: 19089657
- antibodies occur frequently in viral infections, particularly, in HIV but not in bacterial infections PMID: 19089659
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亞細胞定位：Mitochondrion inner membrane; Multi-pass membrane protein.
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蛋白家族：CDP-alcohol phosphatidyltransferase class-I family
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組織特異性：Highly expressed in tissues such as heart, skeletal muscle and liver.
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