CREBZF Antibody

說明書

中文名稱：

CREBZF兔多克隆抗體
貨號：

CSB-PA040131
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9NS37
基因名：

CREBZF
別名：

1110034C16Rik antibody; 6330417B10Rik antibody; AI225749 antibody; AI606244 antibody; CREB/ATF bZIP transcription factor antibody; Crebzf antibody; FLJ94018 antibody; HCF-binding transcription factor Zhangfei antibody; Host cell factor-binding transcription factor Zhangfei antibody; LAZip antibody; LAZipII antibody; SHP-interacting leucine zipper protein antibody; SMILE antibody; ZF antibody; ZHANG_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the C-terminal region of Human Zhangfei.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.
基因功能參考文獻：
1. Zhangfei/CREBZF stabilizes p53 and co-localizes with it in cellular nuclei; the bLZip domain of Zhangfei is required for its profound effects on cell growth and interaction with p53. PMID: 24200963
2. Zhangfei had a suppressive effect on most unfolded protein response genes. PMID: 24155933
3. Results indicate that Ursodeoxycholic acid (UDCA) activates SMILE gene expression, which leads to repression of liver X receptor alpha (LXRalpha)-mediated hepatic lipogenic enzyme gene expression. PMID: 24265317
4. Our objective was to determine the molecular mechanisms by which Zhangfei influences medulloblastoma cell lines PMID: 22798206
5. The transcription factor CREBZF is a novel positive regulator of p53. PMID: 22983008
6. CREBZF, a novel Smad8-binding protein. PMID: 22707059
7. a microarray study of SMILE knock-down and PMA activation in HeLa cells was compared to earlier analysis based on microarray data of kidney allograft tolerance and rejection to determine possible new genes and gene networks involved in kidney transplantation PMID: 22134986
8. the curcumin/LKB1/AMPK/SMILE/PGC1alpha pathway differentially regulates ER stress-mediated gene transcription PMID: 21994947
9. SMILE is involved in the endoplasmic reticulum stress response, by modulating proteasome activity and XBP-1 transcript expression. This function of SMILE may influence immune cell behavior in the context of transplantation. PMID: 21603654
10. These results indicate that SMILE isoforms regulate the inhibition of estrogen receptor transactivation by SHP in a cell-type-specific manner and act as a novel transcriptional co-regulator in ER signalling. PMID: 18657049
11. findings showed Zhangfei activated the expression of trkA and Egr1 in medulloblastoma cells and caused these cells to display markers of apoptosis PMID: 18719857
12. SMILE is a novel corepressor of ERRgamma, and SIRT1 has a role as a novel repressive mechanism for SMILE and ERRgamma inverse agonist PMID: 19690166
13. ZF suppresses the ability of Luman/CREB3 to activate gene expression PMID: 15705566
14. ZF suppresses the ability of VP16 to activate herpes simplex virus IE gene expression PMID: 16282471
15. ZF binds ATF4/CREB2 and enhances its response to MEK1 activation. PMID: 16343488
16. Zhangfei causes medulloblastoma cells to undergo apoptosis PMID: 18719857
17. In differentiated PC12 cells, Zhangfei activated the trkA promoter and induced the expression of endogenous trkA. PMID: 19016376
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亞細胞定位：

Nucleus. Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1.
蛋白家族：

BZIP family, ATF subfamily
組織特異性：

In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low amounts in heart, lung and liver.
數據庫鏈接：

HGNC: 24905

OMIM: 606444

KEGG: hsa:58487

STRING: 9606.ENSP00000433459

UniGene: Hs.535319

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