CPSF1 Antibody

說明書

產品詳情

Uniprot No.：

Q10570
基因名：

CPSF1
別名：

CPSF1 antibody; CPSF160Cleavage and polyadenylation specificity factor subunit 1 antibody; Cleavage and polyadenylation specificity factor 160 kDa subunit antibody; CPSF 160 kDa subunit antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human CPSF1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain.
基因功能參考文獻：
1. Knockdown of CPSF inhibits the proliferation, migration and invasion of ovarian carcinoma cells. PMID: 29358555
2. CPSF1 was identified among protein-binding candidates. A consensus polyadenylation signal AAUAAA is present in intron 6 of IL7 receptor directly downstream from the 5' splice site. Mutations to this site and CPSF1 knockdown increased exon 6 inclusion. PMID: 23151878
亞細胞定位：

Nucleus, nucleoplasm.
蛋白家族：

CPSF1 family
組織特異性：

Widely expressed, with high expression in the retina.
數據庫鏈接：

HGNC: 2324

OMIM: 606027

KEGG: hsa:29894

STRING: 9606.ENSP00000339353

UniGene: Hs.493202

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