CPOX Antibody
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中文名稱：CPOX兔多克隆抗體
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貨號：CSB-PA005910LA01HU
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規格：￥440
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圖片：
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Western Blot
Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate
All lanes: CPOX antibody at 5.7µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 51, 31 kDa
Observed band size: 51 kDa -
IHC image of CSB-PA005910LA01HU diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. -
Immunofluorescence staining of HepG2 cells with CSB-PA005910LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CPOX Polyclonal antibody
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Uniprot No.：
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基因名：CPOX
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別名：Coprogen oxidase antibody; COPROPORPHYRIA antibody; Coproporphyrinogen III oxidase antibody; Coproporphyrinogen Oxidase (CPOX) antibody; Coproporphyrinogen-III oxidase antibody; Coproporphyrinogenase antibody; COX antibody; CPO antibody; Cpox antibody; CPX antibody; HEM 6 antibody; Hem-6 antibody; Hem6 antibody; HEM6_HUMAN antibody; mitochondrial antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial protein (19-149AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，CPOX Antibody (CSB-PA005910LA01HU)，的標記方式是Non-conjugated。對于CPOX Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC, IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:200-1:500 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
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基因功能參考文獻：
- The monomer form of mutated CPOX did not show any activity and homodimeric enzymes derived from Hereditary coproporphyria (HCP) mutant showed low activity (<20% of the control). PMID: 24078084
- Polymorphism of coproporphyrinogen oxidase is associated with genetic susceptibility to the adverse neurobehavioral effects of Hg exposure in children. PMID: 22765978
- Deletion of the fifth exon in the CPOX gene is associated with hereditary coproporphyria. PMID: 21231929
- CPOX polymorphisms are associated with biological media contamination and apoptosis disorders. PMID: 22288185
- competitive action of both uroporphyrinogen decarboxylase and CPO on the same diacetate porphyrinogen substrate provides additional perspectives on the potential existence of abnormal pathways for heme biosynthesis PMID: 21277781
- disease-producing mutations in the CPO gene in nine Swedish families with hereditary coproporphyria PMID: 12181641
- coproporphyrinogen III oxidase sequence matches many structural features from urate oxidase PMID: 12208494
- Modulation of penetrance by the wild-type allele in dominantly inherited erythrohepatic and acute hepatic porphyrias was studied using CPO. PMID: 14669009
- All other type of mutations or missense mutations mapped elsewhere throughout the CPO gene, lead to coproporphyrin accumulation and subsequently typical HCP. PMID: 16159891
- CPO mutations form the structural basis of hereditary coproporphyria. PMID: 16176984
- The Km recognition) and Kcat values for coproporphyrinogen III and IV were determined. PMID: 16258391
- His158 of human CPO may have a role in the active site, but none of the conserved histidine residues of human coproporphyrinogen oxidase is essential for catalytic activity. PMID: 17179900
- The authors report the association of a novel mutation in the coproporphyrinogen oxidase gene in an Irish pedigree with the devlopment of hereditary coproporphyria PMID: 18557518
- Three of the novel missense mutations and one frameshift mutation was detected in coproporphyrinogen III oxidase (CPO) gene in five Italian patients affected by Hereditary Coproporphyria (HCP). PMID: 19267996
- biochemical & kinetic properties of CPOX4, the product of a polymorphism of the CPOX gene that modifies effects of mercury on neurobehavioral function; suggests CPOX4 may predispose to impaired heme biosynthesis which is limited further by Hg exposure PMID: 19339664
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相關疾病：Hereditary coproporphyria (HCP)
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亞細胞定位：Mitochondrion intermembrane space.
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蛋白家族：Aerobic coproporphyrinogen-III oxidase family
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數據庫鏈接：
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