CPD Antibody
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中文名稱：CPD兔多克隆抗體
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貨號：CSB-PA2107ESR1HU
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規(guī)格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA2107ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA2107ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CPD Polyclonal antibody
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Uniprot No.：
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基因名：CPD
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別名：Carboxypeptidase D antibody; CBPD_HUMAN antibody; Cpd antibody; gp180 antibody; Metallocarboxypeptidase D antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Carboxypeptidase D protein (860-1100AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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基因功能參考文獻：
- prolactin induction of VEGF-C and Runx2 was inhibited partly by Carboxypeptidase-D inhibitors, implicating nitric oxide , produced by PRL-regulated Carboxypeptidase-D, in breast cancer progression PMID: 28364216
- Carboxypeptidase-D (CPD) overexpression coincides with high-grade lung cancer and the CPD overexpression could reverse the inhibitory effects of miR-214 PMID: 27494742
- The human carboxypeptidase D transthyretin-like domain forms amyloid under physiological conditions. PMID: 25294878
- Prolactin and R1881, acting through Stat5 and androgen receptor, act cooperatively to stimulate CPD gene transcription in breast cancer cells. PMID: 24433040
- CPD immunostaining and testosterone/prolactin-stimulated CPD expression were higher in prostate cancer than benign tissues/cells. Elevated CPD increased NO production, which was abolished when both androgen and prolactin receptors were inhibited. PMID: 24615730
- Carboxypeptidase D (CPD) is frequently upregulated in hepatocellular carcinoma; targeting CPD inhibits hepatocellular carcinoma cell proliferation through induction of G1 cell-cycle arrest and apoptosis. PMID: 23589395
- Either high glucose or insulin (with low glucose) up-regulates beta-cell CPD (but not CPE). PMID: 21628999
- Palmitoylation of carboxypeptidase D has a role in intracellular trafficking PMID: 12643288
- The isolation and characterization of CPD from several haematopoietic tumour cells are reported. PMID: 15918796
- First report to demonstrate carboxypeptidase D as part of the transforming growth factor (TGF)-beta pathway as a TGF-beta target gene implicated in the pathogenesis of lupus erythematosus. PMID: 17641957
- prolactin or E2 up-regulated CPD mRNA and protein expression in MCF-7 breast cancer cells promoting their survival PMID: 18535109
- CPD releases C-terminal Arg from peptides to provide the precursor substrate for inducible nitric oxide synthase, which enhances nitric oxide synthesis in macrophages. PMID: 11306718
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亞細胞定位：Cell membrane; Single-pass type I membrane protein.
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蛋白家族：Peptidase M14 family
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組織特異性：Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.
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數據庫鏈接：
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