COX15 Antibody

說明書

產品詳情

Uniprot No.：

Q7KZN9
基因名：

COX15
別名：

CEMCOX2 antibody; COX15 antibody; COX15 homolog; cytochrome c oxidase assembly protein antibody; COX15; S. cerevisiae; homolog of antibody; COX15_HUMAN antibody; cytochrome c oxidase assembly homolog 15 (yeast) antibody; Cytochrome c oxidase assembly protein COX15 homolog antibody; cytochrome c oxidase subunit 15 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human COX15.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:5000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

May be involved in the biosynthesis of heme A.
基因功能參考文獻：
1. Mutations of COX15 causing single amino acid conversions are associated with fatal infantile hypertrophic cardiomyopathy and the neurological disorder Leigh syndrome. PMID: 26940873
2. Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy PMID: 12474143
3. A patient with typical clinical and neuroradiological features of Leigh syndrome and cytochrome oxidase deficiency was found to have a mutation in the COX15 gene. PMID: 15235026
4. cdkl3 transfected in anchorage-independent (suspension) HeLa cells overexpressed relative to attached cells and lead to elevated proliferation and viability relative to untransfected. Same in two HEK-293 and a CHO cell lines. PMID: 17945021
相關疾病：

Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 2 (CEMCOX2); Leigh syndrome (LS)
亞細胞定位：

Mitochondrion membrane; Multi-pass membrane protein.
蛋白家族：

COX15/CtaA family
組織特異性：

Predominantly found in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
數據庫鏈接：

HGNC: 2263

OMIM: 256000

KEGG: hsa:1355

STRING: 9606.ENSP00000016171

UniGene: Hs.28326

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