COIL Antibody
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中文名稱：COIL兔多克隆抗體
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貨號：CSB-PA005713GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：COIL
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別名：CLN 80 antibody; CLN80 antibody; COIL antibody; COIL_HUMAN antibody; Coilin antibody; Coilin p80 antibody; p80 antibody; P80 coilin antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human COIL
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.
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基因功能參考文獻：
- The existence of chromatolysis and eccentric nuclei in SMA motor neurons correlates with Cajal body disruption and nucleolar relocalization of coil in, a Cajal body marker. PMID: 22302308
- Data indicate that annexin A2 overexpression in microsatellite instability (MIN) cells induces disassembly and colocalization of coilin with centromeres. PMID: 25347736
- Authors summarize what has been learned in the past 25 years about coilin's structure, post-transcriptional modifications, and interactions with RNA and proteins. [Review] PMID: 25970135
- The study shows that coilin-KO human cells that lack Cajal bodies are phenotypically normal with respect to telomere homeostasis. PMID: 25477378
- Coilin couples snRNA and snoRNA biogenesis, making cajal bodies the cellular hub of small ncRNA metabolism. PMID: 25514182
- The interaction of SMN with the spliceosomal SmD1 (also known as SNRPD1), severely decreases SMN-coilin interaction and prevents Cajal body assembly. PMID: 24413165
- Results suggest that UBL5 could be targeted to Cajal bodies (CBs) via its interaction with coilin. PMID: 23726919
- coilin is subjected to regulated specific proteolysis by calpain, and this processing may play a role in the regulation of coilin activity and Cajal body formation PMID: 23064547
- Data indicate coilin involvement in the processing of telomerase RNA both in vitro and in vivo. PMID: 23274112
- investigated the role of coilin in the DNA damage response and found that coilin reduction correlated with significantly increased levels of soluble gammaH2AX in etoposide treated U2OS cells PMID: 22986342
- new characteristics of coilin in vitro PMID: 22558428
- These results emphasize the role of coilin phosphorylation in the formation and activity of Cajal bodies. PMID: 21991343
- Results identify a novel and unexpected function for coilin, independent of its role in snRNP biogenesis, establishing a new link between the DNA damage response and the inhibition of rRNA synthesis. PMID: 21289084
- Data demonstrate by NMR methods that the carboxy-terminal region contains a Tudor domain. PMID: 20875822
- results suggest the existence of a dynamic flux of coilin between Cajal bodies, nucleoplasm and nucleolus, and indicate that coilin methylation plays a key role in this process PMID: 20449600
- in addition to affecting coilin-coilin interaction and localization in the nucleus, the phosphorylation state of coilin also impacts its interaction with SMN and SmB' and may play a role in controlling U snRNP cycling through the Cajal bodies. PMID: 19997741
- The level of snRNP protein expression and snRNP assembly, rather than the expression levels of p80-coilin, may be a key trigger for Cajal body formation in stable HeLa cell lines. PMID: 11792806
- Coilin is a Cajal body marker; its methylation regulates nuclear body formation. PMID: 12361597
- Specific regions within the C-terminus of coilin, the Cajal Body marker protein, are responsible for regulating the number of nuclear foci. Coilin from various species shows different tendencies to form nuclear foci. PMID: 12482916
- SMN and coilin interact differentially with Cajal bodies and have roles in the pathway for reassembly of nucleoli and Cajal bodies following mitosis PMID: 12679382
- p80 coilin protein co-localizes with ataxin-1 aggregates in the nucleoplasm PMID: 12757932
- specific EB-1/AIDA-1 isoforms, such as AIDA-1c, may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells PMID: 15862129
- Direct interactions between the Cajal body (CB) protein coilin and the promyelocytic leukemia (PML) body protein PIASy have a role in mediating association of CBs to PML bodies. PMID: 16219678
- Complexes of proteasome activator subunit gamma/coilin found in Cajal body - levels of complex increased by UV rays. PMID: 17088425
- Ectopic expression of AGAP2 causes both BRAG2 and the coiled bodies' marker coilin to accumulate in nucleoli. PMID: 17461797
- These findings demonstrate that coilin modifications or levels impact artificial reporter splicing, possibly by influencing small nuclear ribonucleoprotein biogenesis. PMID: 18322647
- FLASH and NPAT positive but not Coilin positive Cajal Bodies correlate with cell ploidy. PMID: 18677100
- Data support a model whereby coilin is the target of an uncharacterized signal transduction cascade that responds to the increased transcription and snRNP demands found in transformed cells. PMID: 19435804
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亞細胞定位：Nucleus. Nucleus, Cajal body.
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蛋白家族：Coilin family
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組織特異性：Found in all the cell types examined.
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數據庫鏈接：
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