CNTNAP1 Antibody
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中文名稱：CNTNAP1兔多克隆抗體
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貨號：CSB-PA005692ESR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA005692ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human glioma using CSB-PA005692ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CNTNAP1 Polyclonal antibody
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Uniprot No.：
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基因名：CNTNAP1
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別名：Caspr antibody; Caspr1 antibody; CNTNAP antibody; Cntnap1 antibody; CNTP1_HUMAN antibody; Contactin associated protein 1 antibody; Contactin-associated protein 1 antibody; MHDNIV antibody; NCP1 antibody; Neurexin 4 antibody; Neurexin IV antibody; Neurexin-4 antibody; Nrxn4 antibody; p190 antibody; Paranodin antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Contactin-associated protein 1 protein (20-300AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells.
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基因功能參考文獻：
- E. coli exploits Caspr1 as a host receptor for penetration of the blood-brain barrier, resulting in meningitis PMID: 29895952
- In two brothers with severe congenital hypotonia and foot deformities, we identified compound heterozygous variants in CNTNAP1, reporting the first causative missense variant, p.(Cys323Arg). Motor nerve conductions were markedly decreased. PMID: 27782105
- CNTNAP1 mutations were found to induce characteristic ultrastructural lesions of the paranodal region. PMID: 27818385
- report a consanguineous Arab family from Qatar with three children having an early lethal form of arthrogryposis multiplex congenita and a novel frameshift mutation in CNTNAP1 PMID: 28254648
- Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects PMID: 24319099
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相關疾?。?/div>Lethal congenital contracture syndrome 7 (LCCS7)亞細胞定位：Membrane; Single-pass type I membrane protein. Cell junction, paranodal septate junction.蛋白家族：Neurexin family組織特異性：Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis.數據庫鏈接：
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