CNTN4 Antibody

說明書

中文名稱：

CNTN4兔多克隆抗體
貨號：

CSB-PA068627
規(guī)格：

￥2024
圖片：
Immunofluorescence analysis of A549 cells, using CNTN4 antibody.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) CNTN4 Polyclonal antibody
Uniprot No.：

Q8IWV2
基因名：

CNTN4
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from internal of Human CNTN4.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:100-1:500

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
基因功能參考文獻：
1. High CNTN4 expression is associated with Pheochromocytomas and Paragangliomas. PMID: 28938490
2. Association between contactin 4 (CNTN4) and antisaccade and P300 in schizophrenia. PMID: 27995817
3. SNPs within the CNTN4 gene are associated with increased risk of oral cancer. PMID: 28595731
4. SNPs in ITPR1 and CNTN4 are involved in the regulation of serum uric acid concentrations in Mexican Americans PMID: 27039371
5. By combining methylation and SNP data, CNTN4 was identified as a risk factor for regular alcohol use. PMID: 26146898
6. data reveal critical and novel roles for CNTN4/amyloid precursor protein in promoting target-specific axon arborization PMID: 25959733
7. We identified CNTN4 as a novel candidate gene for POAG. PMID: 24764060
8. these results suggest that rare copy number variations in CNTN4 may also influence autism susceptibility in Asian populations. PMID: 22750301
9. Using array comparative genome hybridization (CGH), we identified a maternally inherited approximately 535 kb deletion at 3p26.3 encompassing the 5' end of the contactin 4 gene (CNTN4) in a patient with autism. PMID: 21308999
10. Our results demonstrate the association of CNTN4 disruption with the 3p deletion syndrome phenotype and strongly suggest a causal relationship PMID: 15106122
11. The contactin 4 gene (CNTN4) is associated with cerebellar degeneration in spinocerebellar ataxia type 16. Additional studies are necessary to prove 4,256C-->T to be a causative mutation. PMID: 17030759
12. pathological examinations and molecular biological examinations are needed to confirm that this mutation is a true cause of SCA16 PMID: 17915252
13. This report suggests that mutations affecting CNTN4 function may be relevant to Autism spectrum disorder pathogenesis. PMID: 18349135
14. results do not support the candidacy of CHL1, CNTN6, and CNTN4 as tumor suppressor genes in the 3p26-pter region in ovarian cancer PMID: 19509545
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相關(guān)疾病：

A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features.
亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
蛋白家族：

Immunoglobulin superfamily, Contactin family
組織特異性：

Mainly expressed in brain. Highly expressed in cerebellum and weakly expressed in corpus callosum, caudate nucleus, amygdala and spinal cord. Also expressed in testis, pancreas, thyroid, uterus, small intestine and kidney. Not expressed in skeletal muscle
數(shù)據(jù)庫鏈接：

HGNC: 2174

OMIM: 607280

KEGG: hsa:152330

STRING: 9606.ENSP00000380602

UniGene: Hs.298705

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