CNOT9 Antibody, FITC conjugated
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中文名稱：CNOT9兔多克隆抗體, FITC偶聯
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貨號：CSB-PA842140LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CNOT9 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：CNOT9 antibody; RCD1 antibody; RQCD1CCR4-NOT transcription complex subunit 9 antibody; Cell differentiation protein RQCD1 homolog antibody; Rcd-1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human CCR4-NOT transcription complex subunit 9 protein (1-258AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation. Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.
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基因功能參考文獻：
- Data indicate a recurrent somatic C > T change causing a P131L mutation in the RQCD1 (Required for Cell Differentiation1 Homolog) gene identified through whole exome sequencing of 20 metastatic melanomas. PMID: 25544760
- Crystal structures of the DDX6, CNOT1 and CNOT9 complexes. PMID: 24768538
- Crystal structure of the DDX6, CNOT9 and CNOT1 complex. PMID: 24768540
- Our findings in this study imply the functional mechanism of RQCD1 in the Akt activity regulation as a mediator in the EGFR-signaling pathway PMID: 20878056
- mammalian protein is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation PMID: 12356739
- CCR4 plays a role in the regulation of certain endogenous RARalpha target genes and RCD1 and CCR4 might mediate their function through their interaction with NIF-1 PMID: 18180299
- Report involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells. PMID: 19724902
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亞細胞定位：Nucleus. Cytoplasm, P-body.
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蛋白家族：CNOT9 family
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組織特異性：Detected in spleen, thymus, prostate, testis, ovary and intestine.
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