CNOT8 Antibody

說明書

中文名稱：

CNOT8兔多克隆抗體
貨號：

CSB-PA005673GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9UFF9
基因名：

CNOT8
別名：

CAF 1 antibody; CAF 2 antibody; CAF1 antibody; CAF1 like protein antibody; CAF1-like protein antibody; CAF2 antibody; CALIF antibody; CALIFp antibody; CCR4 associated factor 8 antibody; CCR4 NOT transcription complex subunit 8 antibody; CCR4-associated factor 8 antibody; CCR4-NOT transcription complex subunit 8 antibody; CNOT 8 antibody; Cnot8 antibody; CNOT8_HUMAN antibody; hCAF1 antibody; PGK promoter directed over production antibody; POP 2 antibody; POP2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human CNOT8
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
基因功能參考文獻：
1. These results indicate that Caf1 and Ccr4 cooperate in mRNA deadenylation and suggest that the enzyme activities of Caf1 and Ccr4 are regulated via allosteric interactions within the nuclease module. PMID: 25944446
2. The loss of CAF-1 p48 subunit causes a strong defect in packaging DNA into nucleosomes. PMID: 24036545
3. show that SMG7 binds directly to POP2, a catalytic subunit of the CCR4-NOT deadenylase complex, and elicits deadenylation-dependent decapping and 5'-to-3' decay of NMD targets PMID: 24115769
4. The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. PMID: 23236473
5. The NOT1 MIF4G domain binds CAF1 through a pre-formed interface and leaves the CAF1 catalytic site fully accessible to RNA substrates. PMID: 22977175
6. N-terminus played a role in modulating hCaf1 activity, stability and aggregation PMID: 22683897
7. Together, these results indicate that Tob mediates the recruitment of Caf1 to the target of CPEB3 and elicits deadenylation and decay of the mRNA. PMID: 21336257
8. Tob interactions with Caf1 and a C-terminal domain of PABPC1 PMID: 20595394
9. CCR4-NOT is the deadenylase that removes poly(A) from messages destabilized by miRNAs in human cells. PMID: 20065043
10. Cellular POP2 protein binds to central adaptor protein ASC and pathogen recognition receptor PAN1, blocking formation of cryopyrin and PAN1-containing inflammasomes, activation of caspase-1, and subsequent processing of bioactive interleukin-1 beta. PMID: 17178784
11. Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT8 binds CNOT6 in yeast two-hybrid assays. PMID: 19558367
12. Data show that efficient cell proliferation requires both CNOT7 and CNOT8, although combined knockdown of both subunits further reduces cell proliferation indicating partial redundancy between these proteins. PMID: 19605561
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

CAF1 family
數據庫鏈接：

HGNC: 9207

OMIM: 603731

KEGG: hsa:9337

STRING: 9606.ENSP00000285896

UniGene: Hs.26703

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