CNBP Antibody
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中文名稱：CNBP兔多克隆抗體
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貨號：CSB-PA005637GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：CNBP
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別名：CCHC type zinc finger nucleic acid binding protein antibody; Cellular nucleic acid binding protein antibody; Cellular nucleic acid-binding protein antibody; CNBP antibody; CNBP_HUMAN antibody; CNBP1 antibody; DM2 antibody; Erythroid differentiation related antibody; PROMM antibody; Proximal myotonic myopathy nucleic acid binding protein antibody; RNF163 antibody; Sterol regulatory element binding protein antibody; ZCCHC22 antibody; Zinc finger protein 273 antibody; Zinc finger protein 9 (a cellular retroviral nucleic acid binding protein) antibody; Zinc finger protein 9 antibody; ZNF9 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Human CNBP
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression. Has a role as transactivator of the Myc promoter. Binds single-stranded RNA in a sequence-specific manner.; Binds G-rich elements in target mRNA coding sequences. Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs.; Binds to RNA.; Binds to RNA.; Binds to RNA.; Binds to RNA.; Binds to RNA.
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基因功能參考文獻(xiàn)：
- The authors report a previously unknown long noncoding RNA which, together with CNBP, is involved in the fine-tuned regulation of CCND1 mRNA stability, without which CCND1 exhibits, at most, partial expression. PMID: 29199958
- [CCTG]n repeat expansion, differently from the DM1 mutation, does not influence the methylation status of the CNBP gene and other molecular mechanisms are involved in the pathogenesis of Myotonic Dystrophy type 2.. PMID: 29291944
- RNA sequence preferences of unconventional RNA-binding proteins, Nudt21 and CNBP, has been described. PMID: 27956239
- A second point is that DM mutations, although located in noncoding regions, may reduce the expression of mutant alleles, raising questions whether loss-of-function may contribute to the phenotype, or possibly impose a safety limit on knockdown therapies that create or aggravate a DMPK or CNBP deficiency state PMID: 28376341
- CNBP is supporting translation by resolving stable structures on mRNAs. PMID: 28329689
- A G-rich motif in the lncRNA Braveheart interacts with Cnbp to specify the cardiovascular lineage. PMID: 27618485
- The cnbp overexpression rescued the Treacher Collins Syndrome phenotype in a dose-dependent manner by a reactive oxygen species-cytoprotective action that prevented the redox-responsive genes' upregulation but did not normalize the synthesis of ribosomal RNAs. PMID: 27711076
- High CNBP expression is associated with Medulloblastoma. PMID: 26460945
- CNBP overexpression caused increase of cell death and suppression of cell metastasis through its induction of G-quadruplex formation in the promoter of hnRNP K resulting in hnRNP K down-regulation PMID: 24594223
- Arginine methylation of CNBP in the RG motif does not change the subcellular localization but regulates its RNA binding activity. PMID: 24726729
- CNBP are novel antigens for SLE patients and the recognition of CNBP might be differentiated dependent on the level of arginine methylation. PMID: 23642268
- suggested a new possibility of CNBP as a potential anti-cancer target based on CNBP's biological function in c-myc transcription PMID: 23774591
- CNBP associates with the poly(A) binding protein and accumulates in stress granules. PMID: 23285195
- The co-segregation of Myotonic dystrophy type 2 with a recessive CLCN1 mutation provided the explanation for the unusual clinical findings for juvenile onset of myotonia in a 14-year-old female with Myotonic dystrophy type 2 and her affected mother PMID: 22407275
- Myotonic dystrophy 2(autosomal dominant, multisystem disorder caused by a CCTG tetranucleotide repeat expansion located in intron 1 of the zinc finger protein 9 gene (ZNF9 gene) on chromosome 3q 21.3.) described in Israeli Jewish European ancestry. PMID: 22332444
- CCTG repeat expansions in the CNBP gene are responsible for myotonic dystrophy type 2. PMID: 21204798
- Study concludes that DM2 patients from the Netherlands, including a North-African family, harbor a common haplotype surrounding the ZNF9 gene. PMID: 21224892
- These data suggest that Gis2 is functionally orthologous to ZNF9 and acts as a cap-independent translation factor. PMID: 21277287
- ZNF9 expression in myotonic dystrophy type 2 patients is altered at multiple levels. PMID: 20971734
- ZNF9 is abundantly expressed in human myofibres, where it is located in the sarcomeric I bands, and no modification of this pattern is observed in myotonic dystrophy type 2 muscles. PMID: 20102514
- Data identify ZNF9 as a regulator of cap-independent translation and indicate that ZNF9 activity may contribute mechanistically to the myotonic dystrophy type 2 phenotype. PMID: 20174632
- Six of seven of the Zn(2+) fingers from the CNBP protein can be used as substitutes for the Zn(2+) finger in the NH(2)-terminal position of HIV-1 nucleocapsid, and thus support virus replication PMID: 12857921
- The proximal myotonic myopathy phenotype is associated with DM2-(CCTG)(n) expansion mutations. PMID: 15261229
- In twenty-six individuals from a family with DM, the CCTG repeats in ZNF9 were found in normal range. PMID: 15476170
- results show that a single nucleotide polymorphism located in the first intron of the ZNF9 gene is in linkage disequilibrium with the DM2 mutation PMID: 15652222
- Results indicate that the (CCTG)n expansion in the ZNF9 intron does not appear to have a direct consequence on the expression of the gene itself. PMID: 16376058
- the downstream molecular effects of a DM2 mutation are triggered by the accumulation of CCUG repeat tract alone and do not decrease ZNF9 expression at the mRNA or protein level PMID: 16624843
- We present two first-degree relatives with an athletic clinical phenotype, pathological evidence of subsarcolemmal vacuolation, and molecular genetic confirmation of DM2(the molecular defect of the zinc finger protein 9 gene) PMID: 17068784
- PCBP2 and ZNF9 stimulate translation of the ornithine decarboxylase internal ribosomal entry site . PMID: 17327219
- These data contribute to the clinical and molecular correlation of ZNF9 gene short expansion in myotonic dystrophy. PMID: 18804219
- Validated occurrence of an unusual TG 3' splice site in intron 3. PMID: 17672918
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相關(guān)疾病：Dystrophia myotonica 2 (DM2)
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亞細(xì)胞定位：Nucleus. Cytoplasm. Endoplasmic reticulum.; [Isoform 1]: Cytoplasm.; [Isoform 2]: Cytoplasm.; [Isoform 4]: Cytoplasm.; [Isoform 5]: Cytoplasm.; [Isoform 6]: Cytoplasm.; [Isoform 8]: Cytoplasm.
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組織特異性：Expressed in the liver, kidney, spleen, testis, lung, muscle and adrenal glands.
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