CMPK1 Antibody

說明書

中文名稱：

CMPK1兔多克隆抗體
貨號：

CSB-PA004391
規格：

￥1090
圖片：
Western Blot analysis of HeLa cells using UMP-CMP Kinase Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P30085
基因名：

CMPK1
別名：

CMK antibody; CMPK 1 antibody; CMPK antibody; cmpk1 antibody; Cytidine monophosphate (UMP CMP) kinase 1 cytosolic antibody; Cytidine monophosphate kinase antibody; Cytidine monophosphate UMP CMP kinase 1 cytosolic antibody; Cytidylate kinase antibody; dCMP kinase antibody; Deoxycytidylate kinase antibody; EC 2.7.4.14 antibody; KCY antibody; KCY_HUMAN antibody; Monophosphatase kinase antibody; OTTHUMP00000009565 antibody; RP11 511I2.1 antibody; UCK antibody; UMK antibody; UMP CMP antibody; UMP CMP kinase antibody; UMP-CMP kinase antibody; UMP/CMP kinase antibody; UMP/CMPK antibody; UMPK antibody; Uridine monophosphate kinase antibody; Uridine monophosphate/cytidine monophosphate kinase antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the N-terminal region of Human UMP-CMP Kinase.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
基因功能參考文獻：
1. Nuclear CMPK1 expression is indicative of poor prognosis in the triple negative breast cancer patients. PMID: 27558661
2. TGF-b1 inhibited the expression of CMPK, which was blocked in the presence of a TGF-b type I receptor, SB431542, and was abolished by the inhibitor of miR-130b-3p, indicating that CMPK is regulated by the TGF-b signalling pathway through the upregulation of miR-130b-3p. PMID: 28414100
3. The role of CMP/UMP kinase (CMPK), an enzyme catalyzes cytidine diphosphate formation, in DNA repair, was investigated. PMID: 25659034
4. CMPK1 and RBP3 are associated with corneal curvature in Asian populations. PMID: 24963161
5. In particular, polymorphisms of the CMPK1 gene seem to provide important prognostic information PMID: 22838950
6. Single-nucleotide polymorphisms in CMPK1 gene is associated with treatment response in non-small cell lung cancer. PMID: 21642870
7. UMP/CMP kinase (EC 2.7.4.14) is not critical for the phosphorylation of CMP, dCMP and maintenance of natural nucleotide pools in cells PMID: 21559290
8. thymidylate synthase/ribonucleotide reductase gene silencing and deoxycytidine kinase::uridine monophosphate kinase fusion gene gene overexpression markedly improved gemcitabine's therapeutic activity PMID: 19568409
9. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. PMID: 11912132
10. UMP/CMP kinase reveals the conformational changes that occur upon substrate binding PMID: 15163660
11. Models for the phosphorylation action and substrate specificity of human UMP/CMP kinase. PMID: 15550676
12. Several uracil vinylphosphonate derivatives had affinities for human UMP-CMP kinase similar to those of dUMP PMID: 17608725
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亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

Adenylate kinase family, UMP-CMP kinase subfamily
組織特異性：

Ubiquitously expressed.
數據庫鏈接：

HGNC: 18170

OMIM: 191710

KEGG: hsa:51727

STRING: 9606.ENSP00000360939

UniGene: Hs.731647

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