CMIP Antibody

中文名稱：

CMIP兔多克隆抗體
貨號：

CSB-PA815577LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA815577LA01HU diluted at 1:600 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CMIP Polyclonal antibody
Uniprot No.：

Q8IY22
基因名：

CMIP
別名：

C-Maf-inducing protein antibody; c-Mip antibody; cmip antibody; CMIP_HUMAN antibody; KIAA1694 antibody; Tc-Mip antibody; TCMIP antibody; Truncated c-Maf-inducing protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human C-Maf-inducing protein (157-274AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CMIP Antibody (CSB-PA815577LA01HU)，的標記方式是Non-conjugated。對于CMIP Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA815577LB01HU	CMIP Antibody, HRP conjugated	ELISA
FITC	CSB-PA815577LC01HU	CMIP Antibody, FITC conjugated
Biotin	CSB-PA815577LD01HU	CMIP Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.
基因功能參考文獻：
1. Genome-wide significant (P < 5 x 10(-8) ) interaction with MTNR1B and joint effects were detected for CMIP intronic rs17197883. PMID: 29691896
2. each copy of CMIP rs2925979_T allele was associated with a 29% higher risk of T2DM in females (p = 9.30 x 10(-4)), while it was not significantly associated with T2DM in males (p = 0.705). PMID: 29597287
3. CMIP knockdown was observed to result in the downregulation of MDM2 and mitogen activated protein kinase (MAPK) expression at the mRNA level and CMIP was a direct target of miR1013p. PMID: 28944848
4. CMIP is oncogenic and could be a potential target for human glioma diagnosis and therapy. PMID: 28744466
5. These findings suggest that CMIP haploinsufficiency is the likely cause of syndromic Autism spectrum disorder in our patients. PMID: 28504353
6. Wilm's tumor protein (WT1) bound to 2 WT1 response elements, located at positions -290/-274 and -57/-41 relative to transcription start site. PMID: 27650733
7. Results suggest that c-mip and RelA define two distinct types of renal damage associated with VEGF-targeted therapies. PMID: 24067439
8. c-mip has an active role in the podocyte disorders of membranous nephropathy. PMID: 23302718
9. These results suggest that alterations in NF-kappaB activity might result from the up-regulation of c-mip and are likely to contribute to podocyte disorders in cases of idiopathic nephrotic syndrome. PMID: 22507836
10. we provide novel evidence that the language-disorder candidate gene CMIP is implicated in reading processes. PMID: 21457949
11. Eight suggestive significant loci were detected with a series of genes expressed within the inner ear that underlie the auditory function, such as: DCLK1, PTPRD, GRM8, CMIP. PMID: 21493956
12. results identify c-mip as a key component in the molecular pathogenesis of acquired podocyte diseases PMID: 20484117
13. Induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes is associated with minimal change nephrotic syndrome in classical Hodgkin lymphoma. PMID: 20200355
14. results suggest that Tc-mip plays a critical role in Th2 signaling pathway and represents the first proximal signaling protein which links TCR-mediated signal to the activation of c-maf Th2 specific factor PMID: 12939343
15. Filamin-A interacts with c-mip/Tc-mip in a new T-cell signaling pathway. PMID: 15128042
16. c-mip inhibits the degradation of I-kappaBalpha and impedes the dissociation of the NF-kappaB/I-kappaBalpha complexes. PMID: 19019440
17. CMIP modulates phonological short-term memory in language impairment. PMID: 19646677
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亞細胞定位：

Nucleus. Cytoplasm.
組織特異性：

Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturatio
數據庫鏈接：

HGNC: 24319

OMIM: 610112

KEGG: hsa:80790

STRING: 9606.ENSP00000446100

UniGene: Hs.594095

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