CLSTN3 Antibody

中文名稱：

CLSTN3兔多克隆抗體
貨號：

CSB-PA871555LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of Hela cells with CSB-PA871555LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CLSTN3 Polyclonal antibody
Uniprot No.：

Q9BQT9
基因名：

CLSTN3
別名：

CLSTN3 antibody; CS3 antibody; KIAA0726Calsyntenin-3 antibody; Alcadein-beta antibody; Alc-beta antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Calsyntenin-3 protein (197-408AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CLSTN3 Antibody (CSB-PA871555LA01HU)，的標記方式是Non-conjugated。對于CLSTN3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA871555LB01HU	CLSTN3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA871555LC01HU	CLSTN3 Antibody, FITC conjugated
Biotin	CSB-PA871555LD01HU	CLSTN3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.
基因功能參考文獻：
1. ApoE expression attenuated intracellular trafficking of APP and Alcbeta PMID: 26213366
2. structure of Calsyntenin 3 and its interaction with neurexin 1alpha PMID: 25352602
3. The C-terminal fragment but not full-length Cst-3 accumulated in dystrophic neurites surrounding amyloidbeta plaques in Tg2576 mouse and Alzheimer disease brains. PMID: 23499467
4. Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation [alcalpha1, alcbeta, alcgamma] PMID: 15037614
亞細胞定位：

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane. Golgi apparatus membrane. Cell junction, synapse, postsynapse. Cell projection, dendrite.
組織特異性：

According to PubMed:12498782, expressed predominantly in the brain and in kidney. Low levels in heart, skeletal muscle, liver, placenta, pancreas and lung. According to PubMed:12972431, predominant expression in brain, and only marginal in kidney. In brai
數據庫鏈接：

HGNC: 18371

OMIM: 611324

KEGG: hsa:9746

UniGene: Hs.535378

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