CLK2 Antibody
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中文名稱：CLK2兔多克隆抗體
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貨號：CSB-PA005558ESR2HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA005558ESR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA005558ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CLK2 Polyclonal antibody
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Uniprot No.：
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基因名：CLK2
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別名：CDC like kinase 2 antibody; CDC-like kinase 2 antibody; CLK 2 antibody; CLK kinase antibody; CLK2 antibody; Clk2 Scamp3 antibody; CLK2_HUMAN antibody; Dual specificity protein kinase CLK2 antibody; hCLK 2 antibody; hCLK2 antibody; Tu52 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Dual specificity protein kinase CLK2 protein (240-499AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN.
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基因功能參考文獻：
- These findings suggest that CLK2 plays a critical role in controlling the cell cycle and survival of glioblastoma PMID: 27050366
- Loss of CLK2 in luminal breast cancer cells leads to the upregulation of epithelial-to-mesenchymal transition (EMT)-related genes and a switch to mesenchymal splice variants of several genes. PMID: 25670169
- LAMMER/Cdc2-like kinase, represented by Doa and its mammalian homolog CLK2, is a critical and conserved component in the regulatory program of the mitosis-to-meiosis switch PMID: 23376537
- AKT activation controls cell survival to ionizing radiation by phosphorylating CLK2, revealing an important regulatory mechanism required for promoting cell survival. PMID: 20682768
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亞細胞定位：Nucleus.; [Isoform 1]: Nucleus. Nucleus speckle.; [Isoform 2]: Nucleus speckle.
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蛋白家族：Protein kinase superfamily, CMGC Ser/Thr protein kinase family, Lammer subfamily
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組織特異性：Endothelial cells. Expressed in androgen-dependent prostate cancer cells.
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數據庫鏈接：
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