CLEC6A Antibody

說明書

中文名稱：

CLEC6A兔多克隆抗體
貨號：

CSB-PA883930
規格：

￥1090
圖片：
Western blot analysis of SH-SY5Y 293T using Dectin-2 antibody. Antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000

Western blot analysis of K562 using Dectin-2 antibody. Antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200
其他：

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靶點詳情

產品詳情

Uniprot No.：

Q6EIG7
基因名：

CLEC6A
別名：

C type lectin domain family 6 member A antibody; C type lectin superfamily member 10 antibody; C-type (calcium dependent; carbohydrate-recognition domain) lectin; superfamily member 10 antibody; C-type lectin domain family 6 member A antibody; C-type lectin superfamily member 10 antibody; CLC6A_HUMAN antibody; CLEC4N antibody; CLEC4N; mouse; homolog of antibody; Clec6a antibody; CLECSF10 antibody; DC associated C type lectin 2 antibody; DC-associated C-type lectin 2 antibody; Dectin-2 antibody; Dectin2 antibody; Dendritic cell associated lectin 2 antibody; Dendritic cell-associated C-type lectin 2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human Dectin-2.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses.
基因功能參考文獻：
1. functions in Kupffer cells to mediate the uptake and clearance of cancer cells PMID: 27872290
2. Data suggest that the specificity and geometry of dectin-2/CLEC6A carbohydrate-binding site provide molecular mechanism for binding of dectin-2 to fungal mannans and also to bacterial lipopolysaccharides, capsular polysaccharides, and lipoarabinomannans that contain mannose-alpha-1--2-mannose disaccharide unit. (CLEC6A = C-type lectin domain containing 6A) PMID: 28652405
3. these data indicate that mannosylated O-antigens from several Gram-negative bacteria augment TLR4 responses through interaction with Dectin-2. PMID: 27358401
4. This study showed a genetic association between Dectin-2 and pulmonary cryptococcosis. PMID: 26129889
5. human plasmacytoid dendritic cells directly recognize A. fumigatus hyphae via Dectin-2 PMID: 25659141
6. our data show a requirement for Dectin-2 in alveolar macrophage induction of cysteinyl leukotrienes and in the initiation of airway inflammation. PMID: 24129160
7. The Dectin-2 possess a single extracellular conserved C-type lectin-like domain and are capable of mediating intracellular signalling either directly, through integral signalling domains, or indirectly, by associating with signalling adaptor molecules. PMID: 23606632
8. human DECTIN-2 has a role in innate immunity PMID: 15810886
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亞細胞定位：

Cell membrane; Single-pass type II membrane protein.
組織特異性：

Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.
數據庫鏈接：

HGNC: 14556

OMIM: 613579

KEGG: hsa:93978

STRING: 9606.ENSP00000371505

UniGene: Hs.591147

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