CLEC5A Antibody

說明書

中文名稱：

CLEC5A兔多克隆抗體
貨號：

CSB-PA163406
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA163406(CLEC5A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA163406(CLEC5A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

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靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q9NY25
基因名：

CLEC5A
別名：

C type lectin domain family 5 member A antibody; C-type lectin domain family 5 member A antibody; C-type lectin superfamily member 5 antibody; CLC5A_HUMAN antibody; CLEC5 A antibody; CLEC5A antibody; CLECSF 5 antibody; CLECSF5 antibody; MDL 1 antibody; MDL-1 antibody; MDL1 antibody; Myeloid DAP12 associating lectin antibody; Myeloid DAP12-associating lectin 1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Synthetic peptide of Human CLEC5A
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses.; (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP. This interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
基因功能參考文獻(xiàn)：
1. MDL-1 is mainly expressed in atherosclerotic lesional macrophages and increased macrophage MDL-1 expression is associated with early plaque progression and promotes macrophage survival. PMID: 29126450
2. this study shows association of rs1285933 single nucleotide polymorphism in CLEC5A gene with dengue severity PMID: 28764923
3. CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis PMID: 27033255
4. Mannose Receptor and CLEC5A on Macrophage first attracts the Dengue Virus with high avidity, and the virus concurrently interacts with CLEC5A in close proximity to form a multivalent hetero-complex and facilitate CLEC5A-mediated signal transduction. Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex. PMID: 27832191
5. The results suggest that CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo and may be considered a therapeutic target in combination with effective antivirals. PMID: 27795434
6. Concordant overexpression of MDL-1 and DAP12 were correlated with increased production of proinflammatory cytokines in rheumatoid arthritis patients. PMID: 24465901
7. Blockade of CLEC5A inhibits NLRP3 inflammasome activation and pyrotopsis in dengue-virus-infected inflammatory macrophages. Thus, DV can activate NLRP3 inflammasome via CLEC5A. PMID: 23152543
8. No significant associations were noted between the genotypes and allele frequency of the 4 CLEC5A tSNPs between controls and Kawasaki disease patients. PMID: 22536019
9. CLEC5A is homodimeric at the cell surface and binds to dengue virus serotypes 1-4. PMID: 21566123
10. CLEC5A expression in monocyte/macrophage and granulocytes is regulated by PU.1. PMID: 21094529
11. The crystal volume per unit weight (VM) was calculated to be 2.34 A3 Da-1, with nine molecules per asymmetric unit and a solvent content of 47.38%. CLEC5A plays an important role in the pathophysiology of dengue-virus-induced disease. PMID: 20057064
12. blockade of CLEC5A-mediated signalling attenuates the production of proinflammatory cytokines by macrophages infected with Dengue virus (either alone or complexed with an enhancing antibody) PMID: 18496526
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亞細(xì)胞定位：

Cell membrane; Single-pass type II membrane protein.
組織特異性：

Highly expressed in bone marrow with lower levels in synovium, lung and bronchus. Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated
數(shù)據(jù)庫鏈接：

HGNC: 2054

OMIM: 604987

KEGG: hsa:23601

STRING: 9606.ENSP00000449999

UniGene: Hs.446235

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