CLDN17 Antibody

說明書

中文名稱：

CLDN17兔多克隆抗體
貨號：

CSB-PA004868
規格：

￥1090
圖片：
Western Blot analysis of Raji BT474 K562 mouse heart mouse skeletal muscle cells using Claudin-17 Polyclonal Antibody
其他：

產品詳情

Uniprot No.：

P56750
基因名：

CLDN17
別名：

CLDN17; UNQ758/PRO1489; Claudin-17
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the C-terminal region of Human Claudin-17.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability.
基因功能參考文獻：
1. The structural features of Cldn17 contributing to anion channel formation are presented in this work. PMID: 26194246
2. Claudin 17 expression was down-regulated in gastric cancer. PMID: 24325792
3. CLDN17, clustered with CLDN8 at human chromosome 21q22.11, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. PMID: 12736707
亞細胞定位：

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
蛋白家族：

Claudin family
組織特異性：

In the kidney, expressed in the proximal tubule and in the Henle's loop. In the distal convoluted tubule, not expressed in all tubules. Not detected in the collecting duct (at protein level).
數據庫鏈接：

HGNC: 2038

OMIM: 617005

KEGG: hsa:26285

STRING: 9606.ENSP00000286808

UniGene: Hs.258589

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