CLCN6 Antibody

中文名稱：

CLCN6兔多克隆抗體
貨號：

CSB-PA005485LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA005485LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

Immunofluorescence staining of U251 cells with CSB-PA005485LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CLCN6 Polyclonal antibody
Uniprot No.：

P51797
基因名：

CLCN6
別名：

Chloride channel 6 antibody; Chloride channel protein 6 antibody; Chloride channel voltage sensitive 6 antibody; Chloride transport protein 6 antibody; ClC 6 antibody; ClC-6 antibody; ClC6 antibody; CLCN6 antibody; CLCN6_HUMAN antibody; KIAA0046 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Chloride transport protein 6 protein (572-869AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CLCN6 Antibody (CSB-PA005485LA01HU)，的標記方式是Non-conjugated。對于CLCN6 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA005485LB01HU	CLCN6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA005485LC01HU	CLCN6 Antibody, FITC conjugated
Biotin	CSB-PA005485LD01HU	CLCN6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:100-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.
基因功能參考文獻：
1. These findings implicate the effect of rare coding variants in CLCN6 in Blood Pressure variation and offer new insights into Blood Pressure regulation. PMID: 26658788
2. A non-synonymous single nucleotide variation (SNV) was identified in the voltage-sensitive chloride channel 6 gene. PMID: 25794116
3. late endosomal ClC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression PMID: 20466723
4. differential sorting of endogenous (late endosomal) versus overexpressed (early and recycling endosomal) ClC-6 is reminiscent of that of other late endosomal/lysosomal membrane proteins PMID: 17534424
亞細胞定位：

Endosome membrane; Multi-pass membrane protein. Note=Detected in detergent-resistant lipid rafts.
蛋白家族：

Chloride channel (TC 2.A.49) family, ClC-6/CLCN6 subfamily
組織特異性：

Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform 3 is only detected in kidney.
數據庫鏈接：

HGNC: 2024

OMIM: 602726

KEGG: hsa:1185

STRING: 9606.ENSP00000234488

UniGene: Hs.193043

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