CKS1B Antibody

說明書

中文名稱：

CKS1B兔多克隆抗體
貨號：

CSB-PA001650
規格：

￥1090
圖片：
Western Blot analysis of Jurkat cells using Cks1 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P61024
基因名：

CKS1B
別名：

CDC2 associated protein CKS1 antibody; CDC28 protein kinase 1 antibody; CDC28 protein kinase 1B antibody; CDC28 protein kinase regulatory subunit 1B antibody; Cell division control protein CKS1 antibody; CKS 1 antibody; CKS-1 antibody; CKS1 antibody; CKS1_HUMAN antibody; Cks1b antibody; Ckshs1 antibody; Cyclin dependent kinases regulatory subunit 1 antibody; Cyclin-dependent kinases regulatory subunit 1 antibody; NB4 apoptosis/differentiation related protein antibody; PNAS 143 antibody; PNAS 16 antibody; PNAS 18 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the N-terminal region of Human Cks1.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IF	1:200-1:1000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
基因功能參考文獻：
1. miR-204 inhibits cell proliferation in gastric cancer by targeting CKS1B, CXCL1 and GPRC5A. PMID: 29283424
2. Multiple myeloma patients with CKS1B amplification are more likely to have additional high-risk cytogenetic abnormalities and a shorter PFS and OS after an auto-HCT. PMID: 27638366
3. Loss of miR-1258 contributes to carcinogenesis and progression of liver cancer through targeting CKS1B. PMID: 27270326
4. High CKS1B gene expression correlates with disease onset and progression of Multiple Myeloma and associated with more extra copies of 1q21. PMID: 28766538
5. we overexpressed CKS1B in multiple cell lines and found increased sensitivity to PLK1 knockdown and PLK1 drug inhibition. Finally, combined inhibition of WEE1 and PLK1 results in less apoptosis than predicted based on an additive model of the individual inhibitors, showing an epistatic interaction and confirming a prediction of the yeast data. PMID: 27558135
6. High expression of Cks1 was significantly associated with lymph node metastasis and survival status in nasopharyngeal carcinoma PMID: 28061788
7. Results show that Cks1 and Cks2 promoted proliferation and prevented apoptosis of hepatocellular carcinoma HepG2 cells. PMID: 26531156
8. Specifically, CKS1B and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1, by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7. PMID: 24205826
9. Regulation of Cks1 protein stability is crucially dependent on specific tyrosine and lysine residues which are potential sites for post-translational modifications. PMID: 25353373
10. We conclude that perturbing the Hsp90 pathway could provide a useful therapeutic strategy in tumors driven by Cks1 overexpression PMID: 25544127
11. Our results suggest a role for CKS1B in the multiple step process of progression of MGUS to MM and show that CKS1B copy gain has a more significant prognostic value than its overexpression. PMID: 24973170
12. CKS1 mRNA and protein expression were increased in esophageal carcinoma. Overexpression of CKS1 was associated with higher grad, regional lymph node invasion, and neoplastic embolus. CKS1 was negatively associated with the p27(kip1) level in the tumor. PMID: 23301842
13. We demonstrated that high expression of CKS1B immunostaining can be one potent prognostic factor for disease-specific survival, metastasis-free survival, and local recurrence-free survival in patients with nasopharyngeal carcinoma. PMID: 23879533
14. Anaplastic multiple myeloma was associated with significantly higher prevalence of CKS1B amplification than non-anaplastic multiple myeloma. PMID: 24169086
15. CKS1B analysis predicts 1q21 amplification and adverse outcome for risk stratification of patients with multiple myeloma. PMID: 20421271
16. cyclin kinase subunit 1B nuclear expression detected by immunohistochemistry is an adverse prognostic factor for patients with multiple myeloma treated with bortezomib therapy PMID: 22047644
17. Cks1 is overexpressed in esophageal squamous cell carcinoma tissues. Overexpression correlates with increased radiotherapy resistance of esophageal squamous cell carcinoma. PMID: 22302047
18. Overexpression of Cks1 or Cks2 in human mammary epithelial and breast cancer-derived cells, as well as in other cell types, leads to override of the intra-S-phase checkpoint. PMID: 21697511
19. In hepatoma cells, Cks1 controlled IL-8 expression by targeting the NF-kappaB regulator IkappaBalpha, which led to NF-kappaB activation, via a p27-independent regulation of IkappaB kinase complex components. PMID: 21917729
20. Over-expression of CKS1B activates both MEK/ERK and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance. PMID: 20930946
21. A significant CKS1B overexpression was observed in oral squamous cell carcinoma and lymph node metastases samples than in oral lichen planus or oral leukoplakia. PMID: 21117028
22. Association between CKS1B protein overexpression and both polysomy and amplification was demonstrated in cutaneous squamous cell carcinoma PMID: 20737481
23. CKS-1B is commonly expressed in mantle cell lymphoma, particularly in aggressive histologic variants, and may be involved in pathogenesis. PMID: 20688354
24. CKS1B overexpression implicates clinical aggressiveness of hepatocellular carcinomas but not p27(Kip1) protein turnover. PMID: 19866239
25. Overexpression of Cks1 and Cks2 is associated with the aggressive tumour behaviours of hepatocellular carcinoma. PMID: 19845855
26. Weak cooperativity in the core causes a switch in folding mechanism between two proteins of the cks family. PMID: 12473461
27. induction of Skp2 and Cks1 degradation in G1 represents a principal mechanism by which APC/C(Cdh1) prevents the unscheduled degradation of SCF(Skp2-Cks1) substrates and maintains the G1 state PMID: 15014502
28. Cks1 overexpression may play an important role for oral squamous cell carcinoma development through Skp2-mediated p27 degradation PMID: 15579456
29. analysis of the protein dynamics of Cks1 PMID: 15772084
30. ubiquitin ligase subunit Cks1 is involved in p27Kip1 down-regulation and may have an important role in the development of aggressive tumor behavior in breast cancer. PMID: 16168119
31. over-expression of CKS1B, mainly due to gene amplification, imparts a poor prognosis in MM, possibly as a result of enhanced degradation of p27Kip1. PMID: 16188652
32. Cks1 expression level regulates melanoma cell growth, most likely through effects on cell proliferation. PMID: 16924241
33. Results show that complex formation between Cks1 and Skp2 causes conformational changes in both proteins in regions distant from the respective binding sites. PMID: 16979657
34. Generally, the observation that the potential oncogene Cks1 is downregulated by the tumor suppressor p53 corresponds well with the idea that p53 employs multiple ways in order to halt the cell cycle. PMID: 17377499
35. Cks1 expression was only correlated with tumor size in renal cell carcinoma. PMID: 18922157
36. These data suggest that Cks1 is an oncogene in the 1q21 amplicon and plays an important role for breast cancer development. PMID: 19161979
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蛋白家族：

CKS family
數據庫鏈接：

HGNC: 19083

OMIM: 116900

KEGG: hsa:1163

STRING: 9606.ENSP00000471505

UniGene: Hs.374378

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