CKMT1A Antibody
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中文名稱：CKMT1A兔多克隆抗體
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貨號：CSB-PA014412
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA014412(CKMT1A/CKMT1B Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA014412(CKMT1A/CKMT1B Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: ×200) -
Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: Mouse crassum intestinum tissue, Primary antibody: CSB-PA014412(CKMT1A/CKMT1B Antibody) at dilution 1/1500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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其他：
產品詳情
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Uniprot No.：
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基因名：CKMT1A
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別名：Acidic-type mitochondrial creatine kinase antibody; CKMT antibody; CKMT1 antibody; CKMT1B antibody; Creatine kinase mitochondrial 1 (ubiquitous) antibody; Creatine kinase mitochondrial 1B antibody; Creatine kinase U type mitochondrial antibody; Creatine kinase U-type antibody; KCRU_HUMAN antibody; Mia-CK antibody; mitochondrial antibody; U-MtCK antibody; Ubiquitous mitochondrial creatine kinase antibody; UMTCK antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthetic peptide of Human CKMT1A/CKMT1B
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:5000 WB 1:1000-1:3000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
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基因功能參考文獻：
- The highly conserved residue E227 acts as the catalytic base to accept the guanidinium proton transferred from creatine in UMTCK. PMID: 27909311
- Mitochondrial creatine kinase CKMT1 is necessary for survival of EVI1-expressing cells in subjects with EVI1-positive AML. PMID: 28191887
- LRRK2 can interact directly with uMtCK to block its entry into mitochondria and its subsequent processing. PMID: 21370995
- CKMT1 is a key regulator of the permeability transition pore through a complex that is distinct from the classical permeability transition pore. PMID: 24522192
- mitochondrial creatine kinase expression in hepatocellular carcinoma may be caused by hepatocarcinogenesis per se but not by loss of mitochondrial integrity, of which ASB9 could be a negative regulator PMID: 24174293
- The results indicated that uMtCK expression is associated with a poor prognosis in breast cancer and might serve as a tumor marker. PMID: 22982673
- Significantly greater creatine kinase carbonylation is associated with chronic obstructive pulmonary disease PMID: 16166745
- Because creatine kinase temporally buffers ATP, these observations support the hypothesis that a deficit in myofibrillar energy delivery contributes to chronic heart failure pathophysiology in human left ventricular hypertrophy. PMID: 16952984
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亞細胞定位：Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
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蛋白家族：ATP:guanido phosphotransferase family
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數據庫鏈接：
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