CKAP2 Antibody
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中文名稱：CKAP2兔多克隆抗體
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貨號：CSB-PA250828
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA250828(CKAP2 Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA250828(CKAP2 Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：CKAP2
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別名：AI461656 antibody; AW228814 antibody; CKAP 2 antibody; Ckap2 antibody; CKAP2_HUMAN antibody; CTCL tumor antigen se20 10 antibody; CTCL tumor antigen se20-10 antibody; Cytoskeleton associated protein 2 antibody; Cytoskeleton-associated protein 2 antibody; DKFZp686L1238 antibody; FLJ10749 antibody; LB1 antibody; se20 10 antibody; TMAP antibody; Tumor and microtubule associated protein antibody; Tumor associated microtubule associated protein antibody; Tumor- and microtubule-associated protein antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Fusion protein of Human CKAP2
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner.
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基因功能參考文獻：
- CKAP2 acts as a functional oncogene in cervical carcinoma development and may exert its function by targeting FAK-ERK2 signaling pathway. PMID: 28522860
- Knockdown of CKAP2 expression effectively suppressed the proliferation and induced the apoptosis by inhibiting the phosphorylation of JAK2/STAT3 of osteosarcoma cells. PMID: 30119212
- High CKAP2 expression is associated with highgrade glioma. PMID: 30066946
- High CKAP2 expression is associated with Ovarian Cancer. PMID: 28933561
- Chromatin CKAP2 is an independent prognostic marker for relapse-free survival in early-stage breast cancer, and could potentially replace the mitotic activity index in clinical evaluation of proliferation activity. PMID: 24887265
- The transcriptional activity of RHOA, SEMA3B, and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors. PMID: 24280143
- expression might be a potential biologic marker for identifying hepatocellular carcinoma patients at risk of early and extensive recurrence after operative resection PMID: 24238125
- CKAP2 is involved in the maintenance of microtubule nucleation sites PMID: 23737987
- GC box was responsible for the cyclic activity of human CKAP2 promoter through the phosphorylation of Sp1, possibly by Cyclin A/Cdk complex. PMID: 22465120
- Findings suggest that the motif surrounding Ser627 ((625) RRSRRL (630)) is a critical for kinase-substrate recognition and for regulation of the subcellular localization of TMAP during mitosis. PMID: 20458174
- TMAP is limited to pre-anaphase stages and suggest that the multiple phosphorylation may not act in concert but serve diverse functions. PMID: 19641375
- CKAP2 comprises nine exons ranging 70-1442 bp and is about 22 kb in size (regulatory regions included). The CKAP2 promoter contains CCAAT (-39...-33) rather than the canonical TATA box, and harbors nine binding sites for six transcription factors PMID: 12500535
- protein is expressed cell cycle dependently and it is involved in cell proliferation PMID: 16876122
- Data show that degradation of TMAP/CKAP2 during mitotic exit is mediated by the anaphase-promoting complex bound to Cdh1 and that the KEN box motif near the N terminus is necessary for its destruction. PMID: 17339342
- CKAP2 is a physiological substrate of anaphase-promoting complex/cyclosome during mitotic exit and that a tight regulation of the CKAP2 protein level is critical for the normal mitotic progression. PMID: 17376772
- Cdk1-cyclin B1-mediated phosphorylation of TMAP is important for and contributes to proper regulation of microtubule dynamics and establishment of functional bipolar spindles during mitosis PMID: 19369249
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亞細胞定位：Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.
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蛋白家族：CKAP2 family
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組織特異性：Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney.
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數據庫鏈接：
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