CIZ1 Antibody

說明書

中文名稱：

CIZ1兔多克隆抗體
貨號：

CSB-PA910444
規格：

￥1100
圖片：
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: CSB-PA910444(CIZ1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9ULV3
基因名：

CIZ1
別名：

CDKI antibody; CDKN1A-interacting zinc finger protein 1 antibody; Cip1-interacting zinc finger protein antibody; CIZ1 antibody; CIZ1_HUMAN antibody; cyclin dependent inhibitor 1A antibody; LSFR1 antibody; Melanoma differentiation-associated protein antibody; NP94 antibody; Nuclear protein NP94 antibody; OPHN3 antibody; P21 antibody; Zinc finger protein 356 antibody; ZNF356 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide of Human CIZ1
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May regulate the subcellular localization of CIP/WAF1.
基因功能參考文獻：
1. data reveal that CIZ1 plays a major role in ensuring stable association of Xist RNA within the Xi territory. PMID: 28923964
2. CIZ1 activates YAP/TAZ signaling in human hepatocellular carcinoma cells. PMID: 26515335
3. CIZ1 is a kinase sensor that promotes initiation of DNA replication at low kinase levels, when in a hypophosphorylated state that is permissive for cyclin-A-CDK2 interaction and delivery to licensed origins. PMID: 25736292
4. The results of this study showed CIZ1 will play a less important role in dystonia patient diagnosis than previously thought because variants of unclear significance are observed in approximately 1% of adult-onset sporadic dystonia patients in Germany. PMID: 25778706
5. Our study demonstrated that CIZ1 played an oncogenic role in the progression of GBC and CIZ1 might be a promising target for the treatment of GBC PMID: 25427641
6. This study suggested that No mutations in CIZ1 in twelve adult-onset primary cervical dystonia families. PMID: 23813719
7. CIZ1 may be involved in colon cancer progression by regulating cell proliferation, cell cycle, apoptosis and colony formation. PMID: 24126760
8. Variant Ciz1 is a strong candidate for a cancer-specific single marker capable of identifying early-stage lung cancer. PMID: 23074256
9. Mutations in CIZ1 may cause adult onset, primary cervical dystonia PMID: 22447717
10. alternatively spliced variant of Ciz1 is associated with cancer. PMID: 20831784
11. data indicate that Ciz1 is localized in the nucleus and is expressed in a wide range of tissues, especially the pancreas and the brain; formulated a consensus DNA sequence, ARYSR(0-2)YYAC, recognized by Ciz1 PMID: 12824700
12. Findings revealed the inherent role of Ciz1, a novel DNA binding and ER coactivator, in amplifying estrogenic responses and promoting breast cancer tumorigenesis. PMID: 17108141
13. conditional exclusion of exon 4 influences the spatial distribution of the Ciz1 protein within the nucleus, showing that CIZ1 alternative splicing could influence organized patterns of DNA replication PMID: 17508423
14. Ciz1 is a nuclear zinc finger protein interacting with p21, and is a DNA replication factor. The region of Ciz1 necessary for the interaction with ERH spans residues 531-644, encompassing its first zinc finger motif PMID: 18081865
15. An isoform of CIZ1 which lacks a glutamine-rich region, due to alternative splicing in exon 8, is upregulated in Alzheimer's brains relative to the full-length CIZ1 protein. PMID: 18583151
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相關疾病：

Defects in CIZ1 may be a cause of adult onset primary cervical dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Cervical dystonia or spasmodic torticollis, the most common form of focal dystonia, is characterized by involuntary contractions of the neck muscles, which produce abnormal posturing of the head upon the trunk.
亞細胞定位：

Nucleus.
數據庫鏈接：

HGNC: 16744

OMIM: 611420

KEGG: hsa:25792

STRING: 9606.ENSP00000362029

UniGene: Hs.212395

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